绿萼梅总黄酮对小鼠抑郁的改善作用

Improvement of total flavonoids from Armeniaca mume var.mume f.viridicalyx on depressive mice

目的研究绿萼梅总黄酮对小鼠的抗抑郁作用。方法采用昆明种小鼠随机分为对照组、阿米替林或氟西汀(20 mg/kg)组、绿萼梅总黄酮(120、240、360 mg/kg)组,每小组各12只,每天ig给药1次。通过小鼠强迫游泳实验、悬尾实验、利血平诱导眼睑下垂和体温降低模型、5-羟基色氨酸(5-HTP)诱导小鼠甩头模型,考察绿萼梅总黄酮的影响。结果绿萼梅总黄酮各剂量均能显著缩短小鼠强迫游泳、悬尾不动时间(P<0.05、0.01);绿萼梅总黄酮240、360 mg/kg能显著抑制利血平诱导的小鼠眼睑下垂和体温降低(P<0.05、0.01),同时能显著增强5-HTP诱导的小鼠甩头次数(P<0.05、0.01)。结论绿萼梅总黄酮对小鼠各模型有抗抑郁的作用。

Objective To study the antidepressant effect of total flavonoids from Armeniaca mume var. mume f. viridicalyx on mice. Methods KM mice were randomly divided into control group, amitriptyline（20 mg/kg） or fluoxetine（20 mg/kg） group, and total flavonoids from Armeniaca mume var. mume f. viridicalyx（120, 240, and 360 mg/kg） groups. Each tem had 12 mice, and mice were ig administered with drugs, once daily. Depressive models by forced swimming test, tail suspension test, reserpine-induced ptosis and hypothermia, 5-HTP-induced head twitches were established to observe the antidepressive effects of total flavonoids from A. mume var. mume f. viridicalyx. Results Total flavonoids from A. mume var. mume f. viridicalyx（120, 240, and 360 mg/kg） could significantly decrease the time of immobility in the forced swimming test and tail suspension test（P〈 0.05, 0.01）. Total flavonoids from A. mume var. mume f. viridicalyx（240, 360 mg/kg） could significantly antagonized the descent of reserpine-induced ptosis and hypothermia（P〈 0.05, 0.01）, and also could significantly increase the numbers of 5-HTP-induced head twitches（P〈 0.05, 0.01）. Conclusion Total flavonoids from A. mume var. mume f. viridicalyx have obvious antidepressant effect on depressive mice model.