速效救心丸联合盐酸地尔硫卓片治疗不稳定型心绞痛的疗效观察

Clinical observation of Suxiao Jiuxin Pills combined with Diltiazem Hydrochloride Tablets in treatment of unstable angina pectoris

目的探讨速效救心丸联合盐酸地尔硫卓片治疗不稳定型心绞痛的临床疗效。方法选取河南省煤炭总医院2015年9月—2016年9月收治的不稳定型心绞痛患者84例,随机分成对照组和治疗组,每组各42例。对照组患者口服盐酸地尔硫卓片,30 mg/次,3次/d。治疗组在对照组的基础上口服速效救心丸,6粒/次,3次/d。两组患者连续治疗14 d。评价两组患者的临床疗效、心绞痛症状以及心功能改善情况。结果治疗后,对照组和治疗组的总有效率分别为80.95%和95.24%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗后,两组患者心绞痛发作频率、心绞痛持续时间以及心电图ST段位移均有明显下降,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组上述心绞痛症状明显优于对照组患者,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者收缩压、心率、心肌缺血总负荷以及心肌耗氧量均明显下降,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组患者的心率、心肌缺血总负荷和心肌耗氧量明显低于对照组患者,两组比较差异有统计学意义(P<0.05)。结论速效救心丸联合盐酸地尔硫卓片治疗不稳定型心绞痛在临床疗效、心绞痛症状、心功能指标改善情况等方面均要优于单独使用盐酸地尔硫卓片,具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Suxiao Jiuxin Pills combined with Diltiazem Hydrochloride Tablets in treatment of unstable angina pectoris. Methods Patients（84 cases） with unstable angina pectoris in The Coal General Hospital of Henan Province from September 2015 to September 2016 were randomly divided into control and treatment groups, and each group had 42 cases. Patients in the control group were po administered with Diltiazem Hydrochloride Tablets, 30 mg/time, three times daily. Patients in the treatment group were po administered with Suxiao Jiuxin Pills on the basis of the control group, 6 pills/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy, the change of angina pectoris symptoms and cardiac function in two groups before and after treatment were evaluated. Results After treatment, the clinical efficacies in the control and treatment groups were 80.95% and 95.24%, respectively, and there was difference between two groups（P〈0.05）. After treatment, attack frequency, duration, and electrocardiogram ST segment shift in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the angina pectoris symptoms in the treatment group were significantly better than that in the control group, with significant difference between two groups（P〈0.05）. After treatment, systolic pressure, heart rate, total ischemia burden, and myocardial oxygen consumption in two groups was significantly decreased, and there was difference in the same group（P〈0.05）. And heart rate, total ischemia burden, and myocardial oxygen consumption in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Suxiao Jiuxin Pills combined with Diltiazem Hydrochloride Tablets is better than the use of Diltiazem Hydrochloride Tablets alone in clinical efficacy, angina pectoris symptoms, and cardiac function in treatment of unstable angina pectoris, which has a certain clinical application value.