顺铂心脏毒性的研究进展

Research progress on cardiotoxicity induced by cisplatin

作为广谱的细胞毒性抗肿瘤药物,顺铂具有显著的临床疗效,但随着剂量增加出现的心脏毒性反应明显增加了肿瘤患者心血管疾病的风险。目前顺铂产生心脏毒性的机制主要包括细胞毒作用、氧化应激与炎症、心肌细胞凋亡和相关信号通路。重视顺铂心脏毒性的机制,加强对化疗患者心脏的监护与管理,积极研发特效的心脏保护剂,以提高化疗的质量。主要对顺铂产生心脏毒性的临床表现、病理特征、作用机制、药物相互作用及临床防护措施的研究进展进行综述。

As a commonly used cytotoxic antitumor drug, cisplatin has a major clinical efficacy. However, dose-dependent cardiotoxicity significantly increased the risk of cardiovascular disease. The mechanism of cardiotoxicity induced by cisplatin mainly includes cytotoxic effect, oxidative stress and inflammation, myocardium cell apoptosis, and related signaling pathways. The mechanism of cardiotoxicity induced by cisplatin is valued, the monitoring and management of heart of chemotherapy patients is strengthened, and new protective drugs to improve quality of chemotherapy are developed. Research progress on clinical manifestation, pathological characteristics, mechanism, drug interactions, and clinical preventive measures were summarized in this paper.