补肺益肾方提高慢性阻塞性肺疾病患者活动耐力的临床研究

Clinical Study of the Improvement of Activity Endurance in the Patients of Chronic Obstructive Pulmonary Disease Treated with the Formula for Lung and Kidney Tonification

目的观察补肺益肾中药复方联合西药常规治疗慢性阻塞性肺疾病(COPD,简称慢阻肺)的临床疗效。方法将120例稳定期COPD患者随机分为治疗组与对照组各60例,对照组给予西医常规治疗,治疗组在对照组基础治疗的基础上予中药治疗。比较两组治疗前后呼吸困难指数(m MRC)、慢性阻塞性肺疾病评估测试评分(CAT)、圣乔治呼吸问卷(SGRQ)、焦虑自评量表(SAS)与抑郁自评量表(SDS)、6 min步行试验(6MWD)、第1秒用力呼气容积/预计值(FEV1%)及治疗后总体临床疗效。结果治疗组治疗后m MRC、CAT、SGRQ症状与活动评分、SDS、6MWD及总体临床疗效优于对照组(P<0.05),两组FEV1治疗前后均无明显改善。结论补肺益肾中药复方可显著改善稳定期COPD患者的活动耐力、生活质量等综合性评价指标。

Objective To observe the impacts of Chinese herbal compound formula for lung and kidney tonification combined with routine western medicine on the effect evaluation indexes of activity endurance in the patients of chronic obstructive pulmonary disease（ COPD）. Methods One hundred and twenty patients of stable COPD were randomized into a treatment group and a control group,60 cases in each one. In the control group,the routine western medicine was used. In the treatment group,on the basis of the treatment as the control group,Chinese medicine was used. The results of m MRC,CAT,SGRQ,SAS,SDS,6MWD,FEV1% and the total clinical effect were compared between the two groups. Results In the treatment group,the scores of m MRC,CAT,SGRQ symptoms and activity,SDS,6MWD and the total clinical effect were all superior to the control group（ P〈0. 05）. FEV1 was not improved apparently in the two groups. Conclusion The Chinese herbal compound formula for lung and kidney tonification significantly improves the comprehensive evaluation indexes such as activity endurance and living quality in the patients of stable COPD.