厚朴排气合剂治疗胃食管反流性咳嗽的疗效观察

Clinical efficacy of Houpu Paiqi mixture in treatment of gastroesophageal reflux cough

目的观察厚朴排气合剂对胃食管反流性咳嗽的临床治疗效果.方法将2014-02/2016-02共收治胃食管反流性咳嗽患者60例,随机分为3组,A组为奥美拉唑肠溶胶囊联合厚朴排气合剂治疗组,B组为奥美拉唑肠溶胶囊、多潘立酮片联合厚朴排气合剂治疗组,C组为奥美拉唑肠溶胶囊联合多潘立酮片治疗组.对比3组患者治疗治疗效果、不良反应发生率和复发率.结果A组患者临床治疗总有效率为85.0%,B组患者临床治疗总有效率为95.0%,C组患者临床治疗总有效率为80.0%,B组与A组和C组相比,差异具有显著性(P<0.05);A组和C组患者的临床治疗总有效率无显著性差异(P>0.05);A组不良反应发生率为5.0%,B组不良反应发生率为0.0%,C组不良反应发生率为10.0%,3组对比,差异不具有显著性(P>0.05);A组复发率为35.0%,B组复发率为15.0%,C组复发率为45.0%,3组对比,差异不具有显著性(P>0.05).结论厚朴排气合剂辅助治疗胃食管反流性咳嗽具有较好疗效,值得在临床病例中进行大样本研究.

AIM To evaluate the clinical efficacy of Houpu Paiqi mixture in the treatment of gastroesophageal reflux cough.METHODS From February 2014 to February 2016,60 patients with gastroesophageal reflux cough were randomly divided into three groups and treated with omeprazole enteric-coated capsule alone（group A）,omeprazole enteric-coated capsules plus domperidone plus Houpu Paiqi mixture（group B）,and omeprazole entericcoated capsules plus domperidone（group C）.Therapeutic effects,adverse reactions,and recurrence were compared among the three groups.RESULTS The total effective rate was 85.0%for group A,95.0%for group B,and 80.0%for group C,and there was a significant difference between group B and group A or C（P〈0.05）.However,there was no significant difference in the total effective rate between groups A and C（P〈0.05）.There was no significant difference in the incidence of adverse reactions（5.0%for group A,0.0%for group B,and 10.0%for group C） or the rate of recurrence（35.0%for group A,15.0%for group B,and 45.0%for group C）（P〈0.05）.CONCLUSION In patients with gastroesophageal reflux cough,treatment with Houpu Paiqi mixture can not only improve the clinical symptoms,but also reduce the rates of adverse reactions and relapse.