呼出气一氧化氮在哮喘辨证施治中的指导意义

Correlation between Exhaled Nitric Oxide and Asthma Syndrome

目的观察支气管哮喘患者呼出气一氧化氮(Fe NO)与中医辨证分型的相关性,指导中医临床辨证。方法将94例支气管哮喘发作期患者按中医辨证分型为冷哮证、热哮证、风哮证、痰哮证和肺肾两虚证,将检测出的Fe NO进行对比,观察各种证型的Fe NO均数,从而探讨两者之间的相关性。结果风哮证和冷哮证Fe NO积分均数较痰哮证、热哮证、肺肾两虚正均有显著统计学差异(P<0.05),痰哮证Fe NO均数较热哮证、肺肾两虚证有显著统计学差异(P<0.05);风哮证和冷哮证Fe NO均数比较无统计学差异(P>0.05)。结论本研究提示呼出气一氧化氮在哮喘证型中的敏感度由高到低依次为风哮证、冷哮证、痰哮证、肺肾两虚证和热哮证。

Objective To observe the correlation between the exhaled nitric oxide （FeNO） and syndrome differentiation of traditional Chinese medicine （TCM） in patients with bronchial asthma, and to guide clinical differentiation of TCM. Methotls 94 patients with bronchial asthma were divided into two groups according to TCM syndrome differentiation type： Cold Asthma Syndrome, Hot Asthma Syndrome, Wind Asthma Syndrome, Phlegm Asthma Syndrome and Pulmonary and Kidney Deficiency Syndrome, and compared the detected FeNO Type of FeNO, and explore the correlation between the two. Results The average number of FeNO points in wind-asthmatic syndrome and cold-stagnation syndrome was significandy higher than that in sputum-asthenia syndrome, heat-asthmatic syndrome and lung-kidney deficiency syndrome（P〈0.05 ）. There was no significant difference between the two groups（P〉0.05）. There was no significant difference between the two groups （P〉0.05）. Conclusion The study suggests that the exhaled nitric oxide in asthmatic syndrome type from high to low, followed by wind-induced asthma, cold asthma, phlegm, lung deficiency syndrome and heat syndrome.