全真一气汤对肾不纳气证慢性阻塞性肺疾病稳定期患者肺功能、运动耐量及MMP-9的影响

Effect of Quanzhenyiqi Decoction on Pulmonary Function,Exercise Tolerance and MMP-9 in Patients Suffering from stable COPD(chronic obstructive pulmonary disease) of Kidney Failing to Receive Qi Pattern

目的:观察全真一气汤对肾不纳气证慢性阻塞性肺疾病稳定期患者肺功能、运动耐量、血清MMP-9水平的影响,探讨全真一气汤的作用机制。方法:将慢性阻塞性肺疾病肾不纳气证患者分为治疗组40例和对照组40例,对照组予沙美特罗替卡松粉吸入剂,治疗组在对照组治疗的基础上加服全真一气汤,观察两组患者肺功能、动脉血氧分压、运动耐量、血清MMP-9等指标的变化。结果:两组在干预治疗前FVC%、FEV_1%、FEV_1/FVC、MVV%、PaO_2差值、6MWT、MMP-9水平差异无统计学意义(P>0.05);治疗后治疗组FEV_1%、FEV_1/FVC、MVV%以及动脉Pa O2差值、6MWT、MMP-9较对照组有统计学差异(P<0.05)。结论:全真一气汤能够改善肾不纳气慢性阻塞性肺疾病稳定期患者的肺功能、动脉血氧分压、运动耐量等情况,并能降低患者血清中的MMP-9水平。

Objective：To observe the effect of quanzhenyiqi decoction on pulmonary function, exercise tolerance and MMP-9 in patients suffering from stable COPD （chronic obstructive puhnonary disease ） of kidney failing to receive Qi pattern and to explore the functional mechanism of quanzhenyiqi decoction. Methods：The patients suffering from stable COPD of kidney failing to receive Qi pattern were treatment group and control group （40 cases for each group）. The control group was treated with salmeterol for inhalation. On the basis of treatment for control group, the treatment group was given additional quanzhenyiqi decoction. The alteration of indicators such as pulmonary function,arterial oxygen pressure, exercise tolerance, serum MMP-9 in patients of both groups were observed. Results： There was no significant difference in the levels of FVC%, FEV1%, FEV1/FVC, MVV%, PaO2,6MWT and MMP-9 between the 2 groups before intervention （P〉0.05）. The differences of FEV1%, FEV1/FVC, MVV% and arterial PaO2,6MWT and MMP-9 in the treatment group were statistically different from those in the control group （P〈0.05）. Conclusions：Quanzhenyiqi Decoction can improve the general situation of pulmonary function, arterial oxygen pressure, exercise tolerance.etc, and decrease the serum MMP-9 levels in patients suffering from stable COPD of kidney failing to receive Qi pattern.