拉莫三嗪联合丙戊酸钠治疗脑卒中继发癫痫患者的疗效观察

Observation of clinical efficacy of lamotrigine combined with sodium valproate in the treatment of secondary epilepsy after cerebral stroke

目的观察拉莫三嗪联合丙戊酸钠治疗脑卒中继发癫痫患者的临床疗效。方法选取我院2011-01—2012-01收治的80例脑卒中继发癫痫患者为研究对象,将患者抽签速记分为观察组与对照组,每组40例。对照组给予丙戊酸钠治疗,观察组给予拉莫三嗪联合丙戊酸钠治疗,比较2组临床疗效,比较治疗前、治疗6个月、12个月后癫痫发作持续时间、生活质量评分及不良反应发生率。结果观察组有效率95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。2组治疗前癫痫发作持续时间、生活质量评分比较差异无统计学意义(P>0.05);治疗6个月、12个月后癫痫发作持续时间(2.76±1.53)min/次、(2.25±1.23)min/次,低于对照组;生活质量评分(63.82±6.30)分、(78.95±6.71)分,高于对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论拉莫三嗪联合丙戊酸钠治疗脑卒中后继发性癫痫,可提高临床疗效,缩短癫痫发作持续时间,提高生活质量,且不增加不良反应发生率,具有较好的临床应用价值。

Objective To observe clinical efficacy of lamotrigine combined with sodium valproate in the treatment of secondary epilepsy after cerebral stroke. Methods Eighty patients with secondary epilepsy after cerebral stroke in our hospital from January 2011 to January 2012 were selected as study subjects, and they were divided into the observation group and the control group by drawing lots,40 cases in each group. The control group received sodium valproate treatment while the obser- vation group received lamotrigine combined with sodium valproate treatment. Clinical efficacy, epileptic duration before treat- ment and 6 months and 12 months after treatment,quality of life, rate of adverse reactions in the two groups were compared. Results Effective rate of the observation group was 95.00G, significantly higher than 80.00% in the control group（P〈0.05）. There were no significant differences in epileptic duration and quality of life between the two groups before the treat- ment（P〉0.05）. Six and twelve months after treatment,the epileptic duration of the observation group were（2.76±1.53）min/ time and（2.25±1.23）rain/time which were significantly lower than those of the control group,and quality-of-life scores were （63.82±6.30）points and（78.95±6.71 ）points which were significantly higher than those of the control group（P〈0.05）. No significant difference was found in terms of the rate of adverse reactions between the two groups（P〉0.05）. Conclusion Lamotrigine combined with sodium valproate in the treatment of secondary epilepsy after cerebral stroke can improve clinical efficacy,shorten epileptic duration and improve quality of life with no increasing adverse events,which has a good clinical value.