人慢性淋巴细胞白血病转基因动物模型研究进展

Research Progress in Transgenic Animal Models of Chronic Lymphocytic Leukemia——Review

为进一步揭示慢性淋巴细胞白血病(CLL)的发病机制和寻找新的治疗方法,建立合适的转基因动物模型至关重要。现有的人CLL转基因动物模型的建立方法主要是通过模拟CLL相关的遗传变异及基因调控异常来实现的,其中TCL-1转基因小鼠的应用最为广泛。此外,还有miRNA15a/16-1基因敲除小鼠等模型。现就目前人CLL转基因动物模型的最新研究进展作一综述,讨论的主要问题包括TCL-1转基因小鼠及其衍生模型,miR15a/16-1基因敲除小鼠与miR29转基因小鼠,BAFF和APRIL转基因小鼠,BCL-2:Traf2DN双转基因小鼠,IRF4^(-/-)Vh11转基因小鼠等。

Transgenic mouse models of chronic lymphocytic leukemia（CLL） are crucially required for the elucidation of the underlying pathogenic mechanisms and for finding new therapies.So far,several mouse models have been established,mimicking either genetic aberrations or dysregulated gene expression in CLL.Among all the models,TCL1 transgenic model is the most commonly used one.Additionally,there are also other models,such as 13ql4-deletion model.In this review,the major genetically engineered mouse models of CLL in current use are summarized,the main problems include TCL-1 transgenic mice,miR15a/16-l gene knockdown mice and miR29 transgeneic mice,BAFF and APRIL transgeneic mice,BCL-2：Traf2DN double transgeneic mice,rRF4（-/-） Vh11 transgeneic mice and so on.