急性移植物抗宿主病的诊断性生物学标记物研究进展

Advances of Diagnostic Biomarkers on Acute Graft Versus Host Disease——Review

急性移植物抗宿主病(aGVHD)是异基因造血干细胞移植(allo-HSCT)后影响移植总体疗效的主要并发症之一。目前,aGVHD的诊断主要依靠临床表现及靶器官组织的活检。近年来,aGVHD的诊断性生物学标记物成为造血干细胞移植后相关并发症的研究热点,已发现多种miRNA、细胞因子及免疫调节细胞与aGVHD的早期诊断及预后相关。本文从基因水平、蛋白质水平及细胞水平3个层面对aGVHD相关生物学标记物的研究进展作一综述。

Acute graft-versus-host disease（aGVHD） is one of the main complications after allogeneic hematopoietic stem cell transplantation（HCT）,resulting in considerable morbidity and mortality.Diagnosis of aGVHD is typically based on clinical presentation and confirmed by biopsy.In recent years,aGVHD researches have been focused on diagnostic biomarkers,and several microRNAs,cytokines and immunoregulated cells have been dicovered currently.This review summarizes the advances on aGVHD biomarkers.