504株铜绿假单胞菌分布及耐药性分析

Distribution and the drug resistance of 504 pseudomonas aeruginosa isolates

目的:调查山西大医院铜绿假单胞菌的分布特点,并分析其在不同感染部位、不同临床科室之间耐药性的差异。方法:收集分离的铜绿假单胞菌504株,采用K-B法对菌株进行药敏试验,通过WHONET5.6软件对药敏结果进行统计分析。结果:分离得到铜绿假单胞菌主要来源于下呼吸道标本(75.2%),临床感染科室主要以ICU、神经内科、呼吸科、神经外科为主。不同感染部位、不同临床科室分离菌株对同种抗菌药物的耐药率比较差异有统计学意义(P<0.05)。结论:山西大医院呼吸科、ICU、神经内科和神经外科仍然是院内感染控制的重点科室。应加强对头孢哌酮/舒巴坦和亚胺培南的管理及耐药性监测,控制耐药趋势。

Objective：To investigate the distribution and the drug resistance of the P.aeruginosa which isolated from different sites of infection and different clinical department.Methods：Collect 504 P.aeruginosa isolates from the hospitalized patients,the antibiotic suscepitibility testing was performed with K-B method then the results were statistically analyzed by the software WHONET 5.6.Results：The P.aeruginosa strains were mainly isolated from the lower respiratory specimen（75.2%）,most of them were obtained from the patients of ICU,neurology department,respiratory medicine department and neurosurgery department.Cefoperazone/sulbactam and imipenem performed a higher drug resistance.The differences of the drug resistance of P.aeruginosa strains which isolated from different sites of infection and different clinical departments were statistically siginificance（P〈0.05）.Conclution：The key departments for the hospital infection control still were ICU,neurology department,respiratory medicine department and neurosurgery department.It is necessary to enhance the management of the use of cefoperazone/sulbactam and imipenem as well as to monitor the drug resistance of the P.aeruginosa strains so as to reduce the growing of the drug-resistance strains.