含枳术宽中胶囊的四联疗法治疗单纯幽门螺杆菌感染性胃炎的临床回顾性研究

Clinical retrospective study of Zhizhukuanzhong capsule-containing quadruple therapy for gastritis with Helicobacter pylori infection

目的观察含枳术宽中胶囊的四联疗法治疗单纯幽门螺杆菌(Hp)感染性胃炎的疗效。方法治疗组65例,以含枳术宽中胶囊的四联疗法(枳术宽中胶囊+阿莫西林+泮托拉唑+胶体果胶铋)治疗;对照组59例,以四联疗法(阿莫西林+克拉霉素+泮托拉唑+胶体果胶铋)治疗。疗程为2周,分别观察Hp根除率和半年后复发率。结果治疗组和对照组的总有效率分别为89.23%和86.44%,两组比较差异无统计学意义(P>0.05);半年后复发率分别为12.5%和30.56%,两组比较差异有统计学意义(P<0.05)。结论含枳术宽中胶囊的四联疗法治疗单纯幽门螺杆菌感染性胃炎具有良好的疗效,可有效降低Hp根除率,并减少复发。

Objective To evaluate the effect of Zhizhukuanzhong capsule-containing quadruple therapy on chronic gastritis with Helicobacter pylori （Hp） infection. Methods Patients in treatment group （n = 65 ） were treated with quadruple therapy （Zhizhukuanzhong capsule ＋ amoxicillin ＋ pantoprazole ＋ colloidal bismuth pectin） , and patients in control group （ n = 59 ） were treated with quadruple therapy （ maleic acid trimebutine maleate capsule ＋ amoxicillin ＋ pantoprazole ＋ colloidal bismuth pectin）, the treatment lasting for 2 weeks. The Hp eradication rate and recurrence rate after 6 months were evaluated. Results There was no significant difference in the total effective rate between treatment group and control group （89. 23 % vs. 86. 44% , P 〉 0. 05 ） , while the recurrence rate in treatment group was lower than that of control group （ 12. 5% vs. 30. 56% , P 〈 0. 05 ）. Conclusion The Zhizhukuanzhong capsule-containing quadruple therapy has good curative efficacy in the treatment of gastritis with Hp infection, and it can effectively reduce the HP eradication rate and recurrence rate.