艾塞那肽联合川芎嗪对早期2型糖尿病患者肺功能的影响

Effect of exenatide combined with ligustrazine on pulmonary function of patients with early T_2DM

目的观察艾塞那肽联合川芎嗪对早期2型糖尿病(T_2DM)患者肺功能的影响。方法收集早期(肾功能正常且未合并糖尿病视网膜病变)的T_2DM患者随机分为观察组(53例)和对照组(52例)。两组均给予艾塞那肽+二甲双胍+羟苯磺酸钙胶囊,其中观察组在此基础上给予磷酸川芎嗪片,连续治疗30 d后,观察两组患者治疗前后的空腹血糖(FBG)、餐后2 h血糖(2h PBG)、体重指数(BMI)与肺功能[肺活量(VC%)、用力肺活量(FVC%)、一秒用力呼气流量(FEV1%)、最大呼气峰流速(PEF%)、最大自主通气量(MVV%)、肺总量(TCL%)、一秒率(FEV1/FVC%)、肺一氧化碳弥散量(DLCO%)、肺单位体积一氧化碳弥散量(DLCO/VA%)]的变化情况,记录治疗过程中的不良反应。结果治疗后,两组FBG、2h PBG均低于治疗前(P<0.05),但BMI与治疗前比较差异无统计学意义(P>0.05);治疗后两组FBG、2h PBG、BMI比较差异均无统计学意义(P>0.05);治疗后两组患者肺功能均优于治疗前(P<0.05),且观察组优于对照组(P<0.05)。治疗过程中两组均未发生严重不良反应,仅出现轻度恶心与皮肤瘙痒,且两组发生率比较差异无统计学意义(P>0.05)。结论在早期T_2DM患者治疗中加用川芎嗪,能很好地改善患者的肺功能,方法安全可靠。

Objective To observe the effect of exenatide combined with ligustrazine on lung function of patients with early type 2 diabetes mellitus （ T2 DM）. Methods Early T2 DM patients without diabetic kidney disease （DKD） or diabetic retinopathy （DR） were selected and randomly divided into observation group （ n = 53 ） and control group （ n = 52 ）. All the patients in the two groups were given exenatide ＋ metformin ＋ dobes, and observation group were also given ligustrazine, two groups being treated for 30 d. After treatment, the changes of fasting plasma glucose （FBG） 2-hour postprandial blood glucose （2hPBG）, body mass index （BMI）, and pulmonary function （VC%, FVC% ,FEVI% ,PEF% ,MVV% ,TLC% ,FEV1/FVC% ,DLCO% ,and DLCO/VA% ） were observed. Results After treatment, the FBG and 2hPBG of the two groups decreased （P 〈 0. 05 ） ,but no significant difference was observed in BMI （P 〉 0. 05 ）. After treatment, there was no significant difference in FBG,2hPBG or BMI between the two groups （ P 〉 0. 05 ）. After treatment, the pulmonary function was improved in the two groups （ P 〈 0. 05 ） , and observation group was better than control group （ P 〈 0. 05 ）. There was no severe adverse reaction in the two groups during the treatment;there were only mild adverse effects and skin itching, and there was no significant difference on them between the two groups （ P 〉 0. 05 ）. Conclusion Adding ligustrazine can improve the lung function of early T2 DM patients, and the method is safe and reliable.