摘要
随着我国老年化的不断向前发展,骨质疏松及其带来的严重并发症——骨折的发病率也不断提高,已成为威胁老年人生活质量的常见健康问题之一。肠道菌群定植在人体肠道当中,与宿主之间构成一定的互利共生关系,对宿主的代谢及免疫调节发挥着重要的作用。近年来越来越多研究发现肠道菌群不仅对消化系统产生影响,对免疫系统相关疾病也具有重要影响,同时与骨质疏松的发病、发展关系密切。本研究从肠道菌群与免疫系统、骨质疏松与免疫系统、肠道菌群与骨质疏松、骨质疏松的肠道菌群防治等方面进行综述,总结近年来的研究进展及热点,搭建肠道菌群与骨质疏松等相关多学科之间的桥梁,为骨质疏松的菌群治疗、靶点研究奠定基础。
The rapidly evolving aging society in China is associated with increased incidences of osteoporosis and fractures, which have become common health problems that threaten the quality of life of the elderly. Gut microbiota colonizing in the human intestinal tract form a mutual symbiotic relationship with the host and play an important role in the metabolism and immune regulation of the host. In recent years increasing studies have demonstrated that gut microbiota not only affect the digestive system but also contribute to the disease conditions involving the immune system, and have a close relationship with the occurrence and progression of osteoporosis. This review summarizes the progress and hotspots in recent researches of the associations among gut microbiota, the immune system, osteoporosis.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2017年第2期278-282,共5页
Journal of Southern Medical University
基金
国家自然科学基金(81473699)~~
关键词
肠道菌群
骨质疏松
免疫系统
炎症因子
骨代谢
gut microbiota
osteoporosis
immune system
inflammatory factors
bone metabolism