竞争性内源RNA与肿瘤病理机制

Competing endogenous RNA and tumor pathological mechanism

竞争性内源RNA（ceRNA）是一类RNA分子的统称,包括mRNA、假基因、长非编码RNA（lncRNA）、环状RNA（circRNA）.ceRNA通过竞争性结合共同的微小RNA（miRNA）而削弱其对mRNA翻译的抑制作用.多项研究已证实ceRNA失调与乳腺癌、胃癌、淋巴瘤等肿瘤发生密切相关.随着ceRNA的研究深入,其或可作为肿瘤的临床诊断标志及治疗靶点.

Competing endogenous RNA （ceRNA） is a class of RNA which includes mRNA,pseudogenes,long non-coding RNA （lncRNA）,circular RNA （circRNA）.ceRNA weakens its inhibitory effect on mRNA translation through competitive binding with shared microRNA （miRNA）.Many studies have confirmed that the disorder of ceRNA is closely related to the occur-ence of breast cancer,gastric cancer,lymphoma and other tumors.With the improvement of researches,ceRNA may be used as a tumor marker of clinical diagnosis and therapeutic target.