肠易激综合征相关致病因素及发病机制研究进展

The Advances on the Pathogenic Factor and Pathogenesis of Irritable Bowel Syndrome

肠易激综合征(IBS)是一种以腹痛或腹部不适伴有大便性状及排便习惯改变为主要症状的肠道功能性疾病。诊断主要依靠罗马Ⅲ诊断标准,且需除外肠道器质性疾病。目前IBS的发病机制尚不明确,相关研究表明其发病可能与遗传、性别、胃肠道运动障碍、内脏高敏感性、脑肠轴调节异常、肠道感染、肠道菌群失调、饮食及社会心理等因素有关。本文就其可能致病因素及发病机制的最新研究进展作一综述。

Irritable bowel syndrome（IBS）belongs to functional gastrointestinal disorders（FGIDs）,and characterized by recurrent abdominal pain or discomfort in association with altered bowel habits.It is diagnosed by RomeⅢ criteria,and other intestinal disease should be excluded.At present,the pathogenesis of IBS is still uncertain,relevant studies revealed that genetic factors,gender,gastrointestinal motility disorders,increased visceral hypersensitivity,dysregulation of the brain-gut axis,gastrointestinal infection,imbalance of intestinal microbiota,diet and psychosocial factors are associated with IBS.This article will review the recent advances in the research on the pathogenic factor and pathogenesis of IBS.