应用胺碘酮治疗室性心律失常患者的临床效果

Clinical effect of amiodarone in the treatment of patients with arrhythmia

目的探讨应用胺碘酮治疗室性心律失常患者的临床效果。方法选取2014年8月至2015年8月医院收治的150例室性心律失常患者作为研究对象,按随机数字表发将其分为对照组和观察组,各75例。对照组患者采用利多卡因常规治疗方法,观察组患者给予胺碘酮,比较两组患者临床疗效、不良反应发生情况及治疗前后心率。结果观察组治疗有效率为92.0%,对照组治疗有效率为77.3%,观察组患者治疗的有效率显著高于对照组,差异有统计学意义(P<0.05);对照组中有7例(9.3%)出现药物不良反应,观察组中存在不良反应的患者仅有1例(1.3%),观察组患者不良反应发生率显著低于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者心率为(81±4)次/min,明显低于对照组的(90±4)次/min,差异有统计学意义(t=13.58,P<0.05)。结论采用胺碘酮治疗室性心律失常临床疗效显著,能有效降低患者心率,降低不良反应发生率。

Objective To investigate the clinical effect of amiodarone in patients with arrhythmia.Methods In August 2014 to August 2015, 150 cases of ventricular arrhythmia were selected as the research object,randomly divided into control group and observation group,75 cases in each group.Patients in control group were treated with lidocaine conventional treatment,the observation group were given amiodarone,the clinical efficacy,adverse reactions and heart rate before and after treatment were compared between the two groups.Results The effective rate of treatment group was 92%,the effective rate of the control group was 77.3%,effective rate in the observation group was significantly higher than the control group,the difference was statistically significant（P0.05）;the control group had 7 cases of adverse drug reactions（9.3%）,1 cases with existing adverse reactions of patients in the observation group（1.3%）,to observe the occurrence of adverse reactions of patients was significantly lower than the control group,the difference was statistically significant（P0.05）;after treatment,patients in the observation group heart rate（81±4）/min,significantly lower than the control group（90＋4）/min,the difference was statistically significant（t=13.58, P〈0.05）.Conclusion The clinical efficacy of amiodarone in the treatment of arrhythmia is significant,it can effectively reduce the heart rate and reduce the incidence of adverse reactions.