腹腔镜手术和药物保守治疗异位妊娠的疗效和妊娠结局比较

Comparison on Effects and Outcomes Between Laparoscopic Surgery and Conservative Medication for the Treatment of Ectopic Pregnancy

目的探讨腹腔镜手术和药物保守治疗异位妊娠患者的疗效和妊娠结局。方法选择2013年9月至2015年9月我院妇科收治的120例异位妊娠患者分为两组:药物组48例(给予甲氨蝶呤联合米非司酮治疗)和手术组72例(腹腔镜手术治疗),比较两组的疗效和妊娠结局。结果手术组恢复正常血清β-HCG和孕酮值的时间显著短于药物组(P<0.05);手术组治疗后血清β-HCG值和孕酮值明显下降,与治疗前和药物组比较差异具有统计学意义(P<0.05)。手术组的副作用发生率显著低于药物组,输卵管功能明显优于药物组(P<0.05)。结论腹腔镜手术治疗异位妊娠的临床疗效好,副作用少,可作为首选治疗方案。

Objective To explore the curative effects and outcomes between laparoscopic surgery and conservative medication for the treatment of ectopic pregnancy. Methods 120 cases of patients with ectopic pregnancy admitted Department of Gynecology in our hospital from September 2013 to September 2015 were divided into medication group （48 cases, methotrexate ＋ mifepristone） and surgical group （72 cases, laparoscopic surgery）. The curative effects and outcomes were compared between the two groups. Results The time for serum β-HCG and progesterone value returning to normal of the surgical group were significantly shorter than those of the medication group （P 〈0.05）. After treatment, serum β-HCG and progesterone value of the surgical group were significantly lower than those before treatment and those of the medication group （P 〈0.05）. The incidence of side effects of the surgical group was significantly lower than that of the medication group （P〈0.05）. The function of fallopian tube of the surgical group was significantly better than that of the medication group （P 〈0.05）. Conclusions Laparoscopic surgery has better clinical effect and fewer side effects for the treatment of eetopic pregnancy, which can be used as the first treatment option.