转录因子E2F3在胃癌组织中的表达及其预后价值

Expression of transcription factor E2F3 in gastric cancer tissues,and its prognostic value

目的探讨转录因子E2F3在胃癌组织中的表达及其预后价值。方法采用免疫组织化学法检测82例胃癌组织和胃旁组织中E2F3的表达情况,统计分析其表达与临床病理特征及预后的关系。结果胃癌组织中E2F3阳性表达率为65.8%,和癌旁正常胃黏膜组织阳性率(23.2%)比较,差异有统计学意义,P<0.001。E2F3表达与分化程度(P<0.01)、TNM分期(P<0.05)、淋巴结转移(P<0.05)密切相关,而与性别(P=0.131)、年龄(P=0.358)、肿瘤大小(P=0.728)、浸润深度(P=0.367)和其他器官转移(P=0.348)无关。生存期分析提示,E2F3表达阳性患者,相比于阴性表达的,其生存期更短,P<0.01。结论转录因子E2F3与胃癌的发生发展密切相关,其表达与胃癌患者预后紧密相关,具有重要临床意义。

Objective To determine the expression and prognostic value of transcription factor E2F3 in gastric cancer tissues. Methods E2F3 expression in 82 paired of gastric carcinoma tissues and adjacent non- tumor tissues were detected by immunohistochemical method,and the relationship between E2F3 expression and clinicopathological factors as well as prognosis were analyzed. Results Positive expression of E2F3 was detectable in 65.8% of gastric carcinoma tissues and there was significant difference,compared with positive rate in adjacent non-tumor tissues （23.2% ,P〈0.001 ）. Expression of E2F3 was correlated with differentiation （P〈0.01） ,TNM staging （P〈0.05）,and lymph node metastases（P〈0.05）,but not with patient gender（P=0.131）,age（P=0.358）,tumor size（P= 0.728）,invasion depth （P=0.367）,and metastasis to other organs （P=0.348）. Survival analysis showed that the patients with positive expression of E2F3 had shorter overall survival,compared with negative expression （P〈0.01）. Conclusion E2F3 is strongly related with gastric cancer development ＆ aggression and could be a great predictor for gastric cancer prognosis.