银杏酮酯滴丸对PCI术后相关心肌损伤及再发心绞痛随访研究

Follow up Study on the Effects of Ginkgobiloba Extract on Related Myocardial Injury and Recurrent Angina in Patients with PCI Operation

目的探讨银杏酮酯滴丸对PCI术中心肌损伤及术后再发心绞痛的影响。方法选择2014年1月至2015年12月我科收治冠心病行PCI术患者217例,随机被分为治疗组113例(常规西药治疗加服银杏酮酯滴丸)及对照组104例(常规西药治疗)。PCI术前、术后6h、12h、24h,检测血清肌酸激酶同功酶(CK-MB)和肌钙蛋白(cTnI)水平,术后随访再发心绞痛及主要心血管事件(MACE)。结果 PCI术后两组患者血清CK-MB及cTnI水平升高,且术后6h、12h、24h血清CK-MB及cTnI水平对照组高于治疗组,差异有统计学意义(P<0.05);术后心绞痛再发率治疗组(20.4%)低于对照组(32.7%),差异有统计学意义(P<0.05),单因素分析显示治疗组无再发心绞痛及MACE事件显著优于对照组,差异有统计学意义(P<0.05)。结论 PCI术前及术后常规服用银杏酮酯滴丸可减少术后心肌损伤及再发心绞痛的发生率。

Objective To investigate the effects of Ginkgo biloba extract on intraoperative myocardial injury and postoperative recurrence of angina in patients with PCI operation.Methods We chose 217 cases of patients who were admitted to the Department of Cardiology,General Hospital of Panzhihua Iron and steel group with coronary heart disease and underwent PCI operation from January 2014 to December 2015. They were randomly divided into 113 cases of treatment group（ conventional western medicine plus Ginkgo biloba extract） and 104 cases of the control group（ conventional western medicine）.We detected levels of serum creatine kinase isoenzyme（ CK-MB） and cardiac troponin（ cTnI） before and after PCI operation 6h,12 h,24h,and followed up recurrent angina and major cardiovascular events（ MACE） after operation. Results The serum CK-MB and cTnI levels of the two groups increased after PCI operation,and serum CK-MB and cTnI levels 6h,12 h,24h after operation in the control group was higher than that in the treatment group（ P〈0. 05）; postoperative angina recurrence rate in the treatment group（ 20. 4%） was lower than that in the control group（ 32. 7%）（ P〈0. 05）,the single factor analysis showed that rate of no recurrent angina and MACE in the treatment group was significantly lower than that in the control group（ P〈0. 05）.Conclusion Routine use of Ginkgo biloba extract before and after PCI can reduce the incidence of myocardial injury and recurrent angina.