维生素D对毛细支气管炎患儿疗效的影响

Effect of Vitamin D on the Treatment of Children with Capillary Bronchitis

目的探讨维生素D辅助治疗对毛细支气管炎患儿疗效的影响。方法纳入2013年6月至2015年6月收治的73例毛细支气管炎患儿,将患儿采用电脑随机分配的方式分为试验组(n=37)及对照组(n=36)。患儿入院后予抗病毒、抗炎、雾化吸入等常规治疗,试验组在常规治疗基础上于入院治疗当天开始服用维生素D滴剂。统计临床症状消失时间及住院天数,计算治疗有效率,比较两组患儿血清IgA、IgM、IgG、1,25(OH)_2D_3水平。结果两组患儿比较,治疗前IgA、IgM、IgG、1,25(OH)_2D_3差异均无统计学意义(P>0.05)。治疗后,试验组IgA、IgM、IgG、1,25(OH)_2D_3水平均高于对照组,差异有统计学意义(P<0.05)。试验组咳嗽喘憋消失时间、肺部哮鸣音消失时间均明显少于对照组,差异有统计学意义(P<0.05)。试验组住院时间亦少于对照组,但差异无统计学意义(P>0.05)。试验组治愈32例,治愈率86.5%,好转3例,好转率8.1%,有效率94.6%。对照组治愈25例,治愈率69.4%,好转4例,好转率11.1%,有效率80.6%。两组患者有效率比较,差异有统计学意义(P<0.05)。结论维生素D辅助治疗毛细支气管炎能够有效的改善患者的免疫能力,改善临床症状,提升治疗效果。

Objective To investigate the effect of vitamin D adjuvant therapy for capillary bronchitis children.Methods73 cases of children with capillary bronchitis received in our hospital from June 2013 to June 2015 were included and randomly divided into experimental group（n = 37） and control group（n = 36） by computer.The children were given conventional treatment as antiviral,anti-inflammatory,and atomization inhalation care after admission. Children in experimental group took vitamin D drops on the basis of routine treatment,starting on the day of admission.Clinical symptom disappearance time and hospitalization days were recorded,therapeutic response rate was calculated and serum IgA,IgM,IgG,1,25（OH）_2D_3 levels of the two groups were compared.Results Comparing IgA,IgM,IgG,1,25（OH）_2D_3 levels of the two groups before treatment,there was no statistically significant difference（ P〉0. 05）. After treatment,IgA,IgM,IgG,1,25（OH）_2D_3 levels of experimental group were higher than those of control group,the difference being statistically significant（P〈0. 05）. The disappearance time of cough,dyspnea and pulmonary wheeze rale in experimental group was significantly shorter than that of control group,the difference being statistically significant（P〈0. 05）.The hospitalization time of experimental group was also shorter than control group,but the difference was not statistically significant（P〉0. 05）.In the experimental group,32 cases were cured,the cure rate was 86. 5%,conditions of 3 cases were improved,the improvement rate was 8. 1% and the total response rate was 94. 6%.In the control group,25 cases were cured,the cure rate was 69. 4%,conditions of 4 cases were improved,the improvement rate was 11. 1% and the total response rate was 80. 6%.Comparing the response rates of the two groups,the difference was statistically significant（P〈0. 05）.Conclusion Vitamin D adjuvant therapy for capillary bronchitis can effectively improve the immune function and clinical symptoms of patients as well as enhance therapeutic effect.