荧光素钠在脑胶质瘤手术中的定位应用

The positioning application of fluorescein sodium to glioma surgery

目的回顾性研究荧光素钠在脑胶质瘤手术中的定位应用。方法将16例脑胶质瘤患者随机分为对照组与荧光组,荧光组术中应用荧光素钠定位,2组术后进行肿瘤切除率对比,术后3个月按照Karnofsky量表进行对比,术后6个月复查MRI了解肿瘤复发情况。结果对照组肿瘤全切2例,次全切6例;荧光组肿瘤全切7例,次全切1例。术后3个月按照Karnofsky量表(KPS)评分:对照组有效率12.5%,荧光组有效率50%;16例患者术后随访6个月,行MRI复查,对照组肿瘤复发2例,荧光组未发现肿瘤复发。结论应用荧光素钠作为胶质瘤术中的荧光指导,术中可以实时、直观地判断肿瘤边界,有助于缩短手术时间,提高肿瘤全切率,且经济、方便,为后期综合治疗提供基础,延长患者的生存时间。

Objective To retrospectively study the positioning application of fluorescein sodium to glioma operation.Methods sixteen cases with brain glioma patients were randomly divided into control group and fluorescein group which carried out fluorescein sodium to locate during operation.Tumor resection rate,Karnofsky scale three months after operation and brain MRI examination six months after operation were performed.Results Two cases received total tumor resection and six cases received subtotal tumor resection in the control group.Seven cases were treated by total tumor resection and one cases by subtotal tumor resection in the fluorescein group.Karnofsky scale showed that the effective rate of control group was 12.5%and that of fluorescein group was 50%.Brain MRI reexamination during following-up indicated that two cases had tumor recurrence in the control group but no one in the fluorescein group.Conclusion Applying fluorescein sodium which may be regarded as a guideline to glioma operation can judge the tumors＇ edge directly in sight,so it is helpful to shorten operation time and raise the total resection rate by a economic and convenient way.