急性脑梗死与炎症的关系探讨

Study on the relation of acute cerebral infarction and inflammation

目的通过测定急性脑梗死患者血清中炎症标记物白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)含量,探讨其生化指标在急性脑梗死临床诊治中的应用前景及炎症与脑梗死的关系。方法测定60例急性脑梗死患者不同时期及60例健康对照者血清IL-6、CRP含量及NIHSS评分分析炎症与脑梗死的关系。结果血清IL-6、CRP含量在急性脑梗死后逐渐增加,72h达高峰,急性脑梗死患者血清IL-6、CRP含量明显高于对照组(P均<0.01)。结论炎症反应可能参与了急性脑梗死的发生,血清高水平IL-6、CRP有望用于预测脑梗死的预后。

Objective To investigate the dynamic changes of serum inflammatory indicators such as interleukin-6（IL-6）and C-reactive protein（CRP）,in order to predict the application prospect of these indicators to the diagnosis and treatment of acute cerebral infarction as well as explore the relation of acute cerebral infarction and inflammation.Methods The IL-6level CRP level and NIHSS content of 60 patients with acute cerebral infarction in different periods and 60 healthy controls were detected to investigate the relation of acute cerebral infarction and inflammation.Results After acute cerebral infarction the IL-6level and CRP content which were significantly higher in stroke group compared with control group（all P〈0.01）,were increasing gradually and peaked at 72 hours.Conclusion Inflammatory reaction maybe involve in acute cerebral infarction.High levels of IL-6and CRP in the blood were expected to predict the prognosis of cerebral infarction.