糖尿病性黄斑水肿与炎症

The relationship between diabetic macular edema and inflammation

糖尿病性黄斑水肿可引起视网膜细胞受损和视网膜纤维化，是导致患者视力下降的首要原因。其发生和发展与糖基化终末产物、白细胞瘀滞和血管内皮生长因子及其他炎性因子的相互作用有关。采用非甾体类抗炎药、生物降解缓释系统、淋巴细胞功能相关性抗原-1拮抗剂等靶向治疗黄斑水肿已在临床试验中取得一定疗效，为糖尿病性黄斑水肿治疗提供新的方法和思路。

Diabetic macular edema can cause damage to retinal cells and fibrosis, which is the leading cause of diabetic patients＇ visual loss. The occurence and development of disease are related to the interaction of advanced glycation end-products, leukocyte stasis, vascular endothelial growth factor and other inflammatory factors. Targeted therapy for maeular edema, such as nonsteroidal anti-inflammatory drugs, Ozurdex, lymphocyte functionassoeiated antigen-1, and so on, has shown certain curative effect in clinical trials and provides new methods for the treatment of diabetic macular edema.