红细胞分布宽度和D-二聚体联合评估系统性红斑狼疮病情活动程度

The Use of Width of Red Blood Cell Distribution and D-dimer in the Assessment of Systemic Lupus Erythematosus Disease Activity

目的探讨RDW和DD在SLE病情活动中的监测价值。方法收集2015年10月至2016年9月在我院住院的确诊SLE患者123例,根据SLEDAI-2000评分规则对患者疾病活动程度进行评分,将SLEDAI评分<10分计为病情稳定,将SLEDAI评分≥10计为病情活动。收集同期年龄性别匹配的100例健康体检人员作为对照组,比较各组RDW与DD水平,探讨RDW和DD在SLE病情活动程度上的评估价值。结果 SLE患者RDW与DD水平明显高于健康对照组,病情活动组SLE患者的RDW与DD水平显著高于稳定组,当取RDW≥14.65%,DD≥1.66μg/m L为阳性标准,并且采用RDW和DD并联方式作为诊断标准时可以在评估SLE活动程度上获得最好的评估效能。结论采用RDW、DD并联的标准在监测SLE患者的病情发展上有一定的应用价值。

Objective To investigate the diagnostic value of width of red blood cell distribution（RDW） and Ddimer（DD） in the disease activity of systemic lupus erythematosus（SLE）. Methods A total of 123 patients with SLE diagnosed were enrolled from Chinese PLA General Hospital between October, 2015 and September,2016. According to SLEDAI-2000,the disease activity of SLE patients was scored. SLEDAI score 10 was considered as stable condition,while SLEDAI score≥10 was considered as active condition,meanw hile we collected 100 age-and sex-matched patients as control. We compared the RDW and DD levels in each group,and evaluated RDW and DD in SLE disease activity. Results RDW and DD levels of SLE patients were significantly higher than those in healthy controls,while RDW and DD levels of active SLE patients were significantly higher than those in stable group. With RDW and DD in parallel as a diagnostic criterion,we can get the best assessment of performance if using the RDW ≥14. 65% and DD ≥1. 66μg/m L as the positive criteria. Conclusion The standard of RDW and DD in parallel has certain value in monitoring the development of SLE patients.