摘要
Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metasta- sis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV- PyMT, a highly malignant spontaneous breast tumor model, IL-25 （also called IL-17E） was expressed by tumor- infiltrating CD4＋ T cells and macrophages. An IL-25 neu- tralization antibody, while not affecting primary tumor growth, substantially reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells and macro- phages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subse- quent metastasis to the lung. Taken together, our data suggest IL-25 blockade as a novel treatment for metastatic breast tumor.
Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metasta- sis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV- PyMT, a highly malignant spontaneous breast tumor model, IL-25 （also called IL-17E） was expressed by tumor- infiltrating CD4＋ T cells and macrophages. An IL-25 neu- tralization antibody, while not affecting primary tumor growth, substantially reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells and macro- phages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subse- quent metastasis to the lung. Taken together, our data suggest IL-25 blockade as a novel treatment for metastatic breast tumor.
