血清IGF-1、BALP水平与老年女性髋部骨折的相关性

Correlation Analysis of Serum IGF-1,BALP and Hip Fracture in Elderly Women

目的:观察老年女性髋部骨折患者血清胰岛素样生长因子1(IGF-1)、血清骨型碱性磷酸酶(BALP)水平变化,探讨老年女性髋部骨折的相关危险因素。方法:髋部骨折的49例老年女性作为观察组,体检健康的52例老年女性作为对照组;于入院或体检时抽取研究对象的空腹静脉血,采用酶联免疫吸附法(ELISA)测定血清IGF-1、血清骨钙素(BGP)及BALP水平,运用双能X线吸收测定法(DEXA)扫描股骨近端骨密度(BMD)值(观察组扫描健侧);采用Pearson分析观察组患者血清IGF-1、BALP水平与BMD值的相关性,Logistic多因素逐步回归分析老年女性髋部骨折的相关危险因素。结果:观察组患者血清BALP水平显著高于对照组,IGF-1、BMD水平均显著低于对照组(P<0.05);两组血清BGP比较,差异无统计学意义(P>0.05);Pearson结果显示,观察组患者血清IGF-1与BMD呈正相关(r=0.350,P<0.001),BALP与BMD呈负相关(r=-0.426,P<0.001);两组年龄、既往骨折史、户外运动少及日常不补钙钙发生髋部骨折的相关影响因素比较,差异有统计学意义(P<0.05);Logistic分析发现,年龄>70岁、户外运动少及日常不补充钙是老年女性发生髋部骨折的相关危险因素。结论:老年女性髋部骨折时血清IGF-1水平下降和BALP水平上升,适当的户外运动和日常补钙可以减少老年女性髋部骨折。

Objective：To investigate the related risk factors and the changes of serum insulin-like growth factor 1（IGF-1） and serum alkaline phosphatase（BALP） levels in elderly women with hip fracture.Methods：49 elderly female patients with hip fracture were selected as the observation group,and 52 healthy elderly women were selected as the control group.Fasting venous blood were collected when admitted to hospital or during physical check; the serum levels of BMD（IGF-1,BGP,BALP）were tested by ELISA,and BMD value was scanned by DEXA（observation group was scanned by healthy side）; serum correlation between IGF-1,BALP level and BMD value was analyzed by Pearson,and adopting Logistic Multivariate Regression Analysis to analyze correlated risk factors of hip fracture in elderly women.Results：the serum BALP level of the observation group was significantly higher than that of the control group,but the levels of serum IGF-1 and BMD were significantly lower than those of the control group（P〈0.05）; comparison of serum BGP of both groups showed no statistical significance（P〉0.05）; in the observation group,the correlation between IGF-1,BALP and BMD analyzed by Pearson test was positively correlated（r = 0.350,P〈0.001）,BALP was negativelycorrelated with BMD（r =-0.426,P〈0.001）; correlated influencing factors of age,previous fracture history,limited outdoor sports and no calcium supplements in daily meals caused hip fracture showed difference with statistical significance（P〈0.05）; using Multivariate Logistic Regression Analysis found that over 70 years old,limited outdoor sports and no calcium supplements in daily meals were the risk factors to cause hip fracture in elderly women.Conclusion：decreased of level of serum IGF-1 and increased BALP levels were found in elderly women with hip fracture,it suggested that daily calcium supplements and moderate outdoor sports can reduce the risk of hip fractures in elderly women.