膜性肾病易患基因研究进展

Research Progress of Susceptibility Genes of Membranous Nephropathy

膜性肾病(MN)是一种常见的肾病综合征,其发病机制尚不明确,病情反复,迁延不愈。除了环境、免疫炎症反应等因素,遗传因素在其发生和发展的过程中起了较为重要的作用。近年来已发现多种与该病密切相关的易患基因,如主要组织相容性复合体基因、细胞因子相关基因、M型磷脂酶A_2受体编码基因等。因此,对MN易患基因进行深入的研究,对了解MN的发病机制及其诊断与治疗具有重要的临床意义。

Membranous nephropathy（ MN） is one of the most common reasons for adult nephrotic syndrome. With unknown etiology,the condition of the disease is unstable. Besides environmental factors and immune inflammatory factors,genetic factor plays a vital role in the occurrence and development of MN. A variety of susceptibility genes are closely related to MN,such as MHC genes,cytokine genes and M-type phospholipase A2 receptor gene. Therefore,deeper study on the susceptibility genes of MN has a great clinical significance for understanding the pathogenesis,diagnosis and treatment of MN.