卡前列素氨丁三醇在治疗产后出血中的可行性和安全性

The feasibility and safety of Carboprost Tromethamine in the treatment of postpartum hemorrhage

目的探讨卡前列素氨丁三醇治疗产后出血的可行性及安全性。方法选取2013年9月~2016年9月我院产科收治的60例产后出血患者,随机分为对照组和观察组,各30例。观察组给予卡前列素氨丁三醇及缩宫素治疗,对照组采用米索前列醇及缩宫素治疗。比较两组患者产后2 h出血量、止血时间以及临床疗效。结果观察组和对照组产后2 h出血量分别为(185.69±3.95)、(308.26±21.26)ml,止血时间分别为(18.29±2.16)、(35.26±8.29)min,两组比较差异均有统计学意义(P<0.01);观察组的总有效率为96.67%,明显高于对照组的80.00%,观察组不良反应发生率为3.33%,明显低于对照组的23.33%,差异均有统计学意义(P<0.05)。结论卡前列素氨丁三醇治疗产后出血患者的临床效果显著,且安全性高。

Objective To investigate the feasibility and safety of Carboprost Tromethamine in the treatment of postpartum hemorrhage.Methods Sixty cases of postpartum hemorrhage in our hospital from September 2013 to September 2016 were randomly divided into control group and observation group,30 cases in each group.The observation group was treated with Carboprost Tromethamine and Oxytocin,and the control group was treated with Misoprostol and Oxytocin.The hemorrhage amount after 2 h of postpartum,hemostasis time and clinical efficacy were compared between two groups.Results The hemorrhage amount after 2 h of postpartum [（185.69±3.95） ml vs.（308.26±21.26） ml],hemostasis time [（18.29±2.16） min vs.（35.26±8.29） min] of the observation group was significantly less than that of the control group the differences were statistically significant（P〈0.01）.The total effective rate of observation group was 96.67%,which was significantly higher than that of control group（80.00%）,the incidence of adverse reactions in the observation group was lower than that in the control group（3.33% vs. 23.33%）,the differences were statistically significant（P〈0.05）.Conclusion The clinical effect of Carboprost Tromethamine in the treatment of postpartum hemorrhage is significant,and it is safe.