自拟补肾疏肝汤治疗更年期综合征的临床效果观察

Clinical effect observation of Self-Made Bushen Shugan Decoction on treating climacteric syndrome

目的探讨自拟补肾疏肝汤治疗更年期综合征的临床效果。方法选取2011年2月~2015年2月在我科治疗的253例女性更年期综合征患者作为研究对象,随机分为对照组(123例)和观察组(130例)。对照组采用常规西医治疗方法,观察组采用中医滋肾疏肝法治疗。比较两组的治疗效果、症状改善情况、血生化指标情况。结果观察组的治疗有效率为94.62%,显著高于对照组的71.54%,差异有统计学意义(P<0.05)。观察组治疗后的潮热出汗、烦躁易怒、胸胁胀痛、心烦失眠、全身乏力等中医症候积分显著低于对照组,差异有统计学意义(P<0.05)。观察组治疗后的促卵泡生成素、促黄体生成素、血清过氧化脂质水平显著低于对照组,E2、β-内啡肽、IL-2水平显著高于对照组,差异有统计学意义(P<0.05)。结论自拟补肾疏肝汤治疗更年期综合征临床效果显著,有利于缓解症状,调整内分泌,具有积极的临床意义。

Objective To explore the clinical effect of Home-Made Bushen Shugan Decoction on treating climacteric syndrome.Methods From February 2011 to February 2015,253 female cases of climacteric syndrome treated in our department were selected randomly divided into the control group（123 cases） and the observation group（130 cases）.The control group was treated with routine western medicine,the observation group was treated with traditional Chinese herbal medicines with the actions of nourishing the kidneys and soothing the liver.The therapeutic effect,symptomaticimprovement,and blood biochemical indicators in the two groups were compared.Results The therapeutic effective rate in the observation group was 94.62%,which was higher than that in the control group（71.54%）,with significant difference（P〈0.05）.The symptomatic scores of traditional Chinese medicine including tidal fever and sweating,vexation and irrigation,distending pain in the chest and ribs,heart vexation and insomnia,and generalized weakness,etc. after treatment in the observation group was lower than that in the control group,with significant difference（P〈0.05）.The level of folliclestimulating hormone,luteinizing hormone,and lipid peroxidation after treatment in the observation group was lower than that in the control group,the levels of E2,β-endorphin,and interleukin-2 after treatment in the observation group was higher than that in the control group,with significant difference（P〈0.05）.Conclusion Self-Made Bushen Shugan Decoction on treating climacteric syndrome can obtain a remarkable clinical effect,it is effective in relieving symptoms and regulating endocrine,and has positive clinical significance.