氨硫脲片治疗喉结核的效果及对血清氧磷酶水平的影响

Efficacy observation of thioacetazone tablets in the treatment of laryngophthisis and its influence on the levels of PON1 in the serum of patients

目的观察氨硫脲片治疗喉结核疗效及其对患者血清对氧磷酶(PON1)的影响。方法将2010年1月~2015年1月陕西省结核病防治院收治的76例喉结核患者随机分为观察组和对照组,每组38例。所有患者均给予常规抗结核治疗,观察组患者同时给予氨硫脲片治疗,两组疗程均为6个月。治疗后,观察两组疗效及痰菌转阴率。治疗期间,观察两组咳嗽、充血水肿、咽喉肿痛及声音嘶哑等症状的缓解时间。治疗前、治疗后第10、20、30、40、50及60 d分别检测患者血清PON1水平。治疗前后,分别检测患者血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、总抗氧化能力(T-Aoc)及总抗氧化态(TAS)水平。观察所有患者不良反应发生情况。结果观察组总有效率及痰菌转阴率分别为94.7%及68.4%,均明显高于对照组(P<0.05)。治疗后,观察组咳嗽、充血水肿、咽喉肿痛及声音嘶哑等症状的缓解时间均明显短于对照组(P<0.05)。观察组于治疗20 d后PON1水平均明显高于对照组(P<0.05)。治疗后,观察组SOD、GSH-PX、T-Aoc及TAS均明显高于对照组(P<0.05)。所有患者均未出现严重不良反应。结论氨硫脲片治疗喉结核疗效显著,可有效缓解患者症状,增加患者血清PON1水平,且安全性较高,值得进行深入研究。

Objective To.observe the efficacy and safety of thioacetazone tablets in the treatment of laryngophthisis. Methods. 76 patients with laryngophthisis from Jan. 2010 to Jan.2015 in the tuberculosis prevention and control hospital of Shaanxi province were randomly divided into observation group （38 cases） and control group （38 cases）.The regular antituberculosis therapy was given to the patients. The observation group was treated with thioacetazone tablets on the base of regular therapy.After the treatment, the effect, sputum negative conversion rate were observed. Before and after the treatment,the relief time of cough, congestion edema,swollen and painful throat hoarse were observed. Before and 10,20,30,40,50 and 60 day after treatment,the levels of PON1 in the two groups were evaluated. Before and after the treatment,the levels of SOD,GSH-PX,T-Aoc and TAS were detected in the two groups. The adverse reactions during treatment were observed. Results The total effective rate and sputum negative conversion rate were 94.7% and 68.4% in observation group were significantly higher than the control group （P 〈 0.05）.The relief time of cough,congestion edema, swollen and painful throat hoarse in observation group were significantly shorter than the control group （P 〈 0.05）.20 day after treatment, the levels of PON1 in the observation group were significantly higher than the control group （P 〈 0.05）.After treatment,the levels of SOD,GSH-PX,T-Aoc and TAS were significantly higher in observation group than the control group （P 〈 0.05）.And there was no significant difference in the incidence of adverse reactions in the two groups （P 〉 0.05）. Conclusion Thioacetazone tablets has significant efficacy in the treatment of laryngophthisis,could significantly improved the symptoms of patientsl promoted the levels of PON1 and worth to the next study.