多潘立酮混悬液联合奥美拉唑治疗婴儿肺炎合并胃食管反流病的疗效观察

Efficacy of domperidone suspension combined with omeprazole in the treatment of infantile pneumonia complicated with gastroesophageal reflux disease

目的:探讨多潘立酮混悬液与奥美拉唑联合治疗婴儿肺炎合并胃食管反流病的效果。方法:选择2012年1月—2016年1月婴儿肺炎合并胃食管反流病患儿60例,按治疗方法随机分为观察组和对照组,每组30例。观察组给予多潘立酮混悬液与奥美拉唑联合治疗,对照组给予多潘立酮混悬液治疗。对比两组患儿的治疗效果。结果:观察组治疗总有效率为93.3%,明显高于对照组的70.0%,差异有统计学意义(P<0.05)。观察组治疗前胃食管反流病症状评分(3.2±0.5)分,与对照组的(3.3±0.4)分相比,差异无统计学意义(P>0.05)。观察组治疗后胃食管反流病症状评分(1.2±0.7)分,明显低于对照组的(2.8±0.7)分,差异有统计学意义(P<0.05)。结论:多潘立酮混悬液与奥美拉唑联合治疗能有效提高患儿肺炎治疗效果,改善患儿胃食管反流病症状。

Objective ： To investigate the effect of domperidone suspension combined with omeprazole on infants with pneumonia complicated with gastroesophageal reflux disease. Methods：From January 2012 to January 2016 in hospital, the choice of infant pneumonia complicated with gastroesophageal reflux disease in 60 cases as the research object, all patients were randomly divided into treatment group （n = 30） and normal group （n = 30 ）, combined with domperidone suspension group were given routine treatment with omeprazole, the treatment group was treated with domperidone suspension. Treatment effects of two groups were compared. Results：The total effective rate of the treatment group was 93.3% and 70.0% in the control group was significantly higher than that in the control group （P 〈 0. 05 ）, the difference was statistically significant. The symptom score of gastroesophageal reflux disease （3.2 ± 0. 5 ） in the combined group was not different from that in the conventional group （ 3.3 ±0. 4） , and the difference was not statistically significant （ P 〉 0.05 ）. The symptom score （ 1.2 ± 0.7 ） in the treatment of gastroesophageal reflux disease in the combined group was significantly lower than that in the conventional group （ 2.8 ± 0.7 ）, and the difference was statistically significant （ P 〈 0. 05 ）. Conclusion ： Domperidone suspension and omeprazole can effectively improve the therapeutic effect in children with pneumonia,improve the symptoms of gastroesophageal reflux disease.