骨关节炎与骨质疏松的相关性研究

The research on the relationship between Osteoarthritis and Osteoporosis

关于骨关节炎与骨质疏松的相关性研究已有半个世纪,两者的相关性存在很大争议,骨关节炎与骨质疏松作为两种与骨代谢相关的疾病,雌激素、NO、基因遗传、甲状旁腺激素等多种因素对其存在影响。两者均属于与人体衰老密切联系且发病机制并不相同的退行性疾病。有的研究认为两者是对立的,OA患者的BMD是普遍增高的,系列的纵向研究也发现OA患者伴BMD升高其骨折发生率反而增加。有的研究认为BMD增高可以阻止OA的疾病进展。也有一部分学者认为两者并不关联。本文通过查阅国内外近10年的文献,探讨两者的确切关系,应用于临床,使患者受益。

The relationship between osteoarthritis and osteoporosis has been studied for about half a century.However,the relevance of the two diseases is still controversial.Osteoarthritis and osteoporosis as two diseases related to bone metabolism,both are influenced by a number of factors such as estrogen,NO,genetic factors,PTH,etc.Both diseases are degenerative diseases related to human ageing but the pathogenesis is different.Some believe the two diseases are opposite,as OA patients in general have high BMD.However,longitudinal studies have shown that OA patients had higher BMD but increased fracture risk.Some research showed that increased BMD might slow the progression of OA.Some researchers think that there is no relevance between the two.In this review,by reviewing nearly 10 years national and international literature,we explored the exact relationship between the two diseases,with the aim to guide the application in clinical work,and to benefit patients in practice.