颅脑外伤昏迷病人使用抗血小板药对预防静脉血栓的作用

目的:探讨颅脑外伤昏迷病人预防性使用抗血板药物对静脉血栓(VTE)形成的预防和治疗作用。方法:回顾性研究我院从2013年1月至201 6年6月收治的颅脑外伤昏迷(Glasgow评分<8分)并最终存活的病人64例,包括ICU收治的病人。其中32例患者入院72小时后预防性使用抗血小板药物作为治疗组,另外32例未预防性使用抗血小板药物的颅脑外伤昏迷病人作为对照组。使用血浆D-二聚体测定及血小板计数的动态监测及下肢深静脉彩色超声检查评价患者发生血栓性疾病的比率作为比较。结果:观察组有11例发生了血栓栓塞,治疗组仅有两例发生了血栓栓塞。结论:预防性使用抗血小板药物能明显降低颅脑外伤昏迷病人血栓性疾病的发生几率,同时对已形成血栓的病人也有治疗作用。

This thesis aims to investigate the preventive and therapeutic effects of coma patients’using anti-platelet drugs on veG nous thrombosis.A retrospective study finds that from January 2013 to June 201 6,there are 64 surviving cases among coma of patients with craniocerebral trauma or Glasgow coma scores less than 8 points,including patients received by ICU.32 patients who use anti-platelet drugs 72 hours after admission are regarded as a treatment group.Another 32 coma patients who do not use are regarded as a control group.Using Plasma D-dimer,platelet count and the color ultrasound for lower limb deep veins to evaluate the occurrence rate of thrombotic diseases.Finally it is found that there are 1 1 cases of thromboembolism in the observation group,while 2 cases in the therapeutic group.In conclusion,preventive use of anti-platelet drugs can not only significantly reduce the occurrence probability of thrombotic diseases of coma patients,but also has a therapeutic effect on thrombosis patients.