普拉地平的工艺改进

Improvement on Synthesis Process of Pranidipine

目的改进普拉地平的合成工艺。方法以间硝基苯甲醛,3-氨基巴豆酸甲酯和乙酰乙酸肉桂酯为原料,经闭环反应制备普拉地平。结果通过新合成方法,减少了合成步骤,总收率为85.1%。结论本工艺操作简便,成本较低,适于工业化生产。

Objective To improve the synthesis process of pranidipine. Methods Pranidipine was prepared by ring- closing reaction, using 3-nitrobenzaldehyde, methyl 3-aminocrotonate and cinnamyl acetoacetate as starting materials. Results The synthetic steps are reduced through the new method, and the total yield of pranidipine reached 85.1%. Conclusion A simple, easily controlled and cost saving process for the synthesis ofpranidipine was attainable.