晚期氧化蛋白产物对2型糖尿病视网膜病变进展的预测价值

Advanced oxidation protein products in predicting the progression of diabetic retinopathy in patients with type 2 diabetes mellitus

目的探讨晚期氧化蛋白产物(AOPP)能否预测DR进展情况。方法采用前瞻性队列研究方法纳入T2DM患者363例,根据基线AOPP水平四分位点将受试者分为4组(Q1、Q2、Q3、Q4),根据5年随访前后免散瞳眼底摄片结果计算DR进展率。结果随基线AOPP水平升高,5年后DR进展率升高(19.51%vs 28.42%vs 37.36%vs 47.37%,P<0.01)。Logistic回归分析显示,基线AOPP水平是影响DR进展的独立危险因素(OR=1.833,95%CI:1.573~1.982,P<0.05)。基线AOPP水平预测5年后DR进展的曲线下面积(AUC)为0.883(95%CI:0.842~0.924),敏感性和特异性分别为86.1%、91.9%。结论 AOPP可能是预测DR进展的生物标记物之一。

Objective To explore the ability of advanced oxidation protein products（AOPP） in predicting the progression of diabetic retinopathy（DR） in patients with type 2 diabetes mellitus（T2DM）.Methods 363 T2 DM patients were enrolled in this prospective cohort study.According to the quartile points of baseline AOPP level,patients were divided into four groups（Q1,Q2,Q3 and Q4）.The progression rate of DR was calculated according to the changes of non-mydriatic fundus photography after a 5-year follow-up.Results With the increase of baseline AOPP level,the rate of progression of DR increased（19.51%vs 28.42%vs 37.36%vs 47.37%,P〈0.01）.Logistic regression analysis showed that baseline level of AOPP was an independent risk factor for the progression of DR（OR=1.833,95%CI：1.573-1.982,P〈0.05）.Area under the curve of AOPP in predicting DR is 0.883（95%CI：0.842-0.924） with the sensitivity 86.1%and specificity 91.9%.Conclusion AOPP may be one of the biomarkers for the prediction of type 2 diabetic retinopathy progression.