摘要
体重增加是T2DM患者降糖过程中的不良反应。PROactive研究证实,T2DM合并心血管危险因素的患者,心血管事件增加的危险因素是体重降低而非体重增加。本文旨在对T2DM患者体重变化与心血管疾病及死亡的随机对照研究(RCT)进行综述,共12篇相关研究入选,认为体重增加并非糖尿病患者的绝对危险因素,需个体化综合分析。
Obesity is recognized as a significant risk factor for type 2 diabetes（T2DM）.However,the recent PRO active study indicated that weight loss but not weight gain was associated with increased cardiovascular disease（CVD） events in patients with T2 DM and cardiovascular risk.Thus we reviewed randomized controlled trials（RCT） to analyze the effect of weight change on cardiovascular morbidity and mortality in patients with T2 DM.A total of 12 RCTs were included and analyzed.So far,weight gain could not be proved to be a definite risk factor for patients with T2 DM.There are many challenges ahead as we seek to better understand the energy balance in individuals.
作者
陈芳
卢岚敏
韩白玉
陆菊明
CHEN Fang LU Lan-min HAN Bai-yu et al(Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2017年第2期185-188,共4页
Chinese Journal of Diabetes
关键词
糖尿病
2型
生活方式干预
心血管疾病风险
体重变化
死亡
Diabetes mellitus
type 2
Lifestyle intervention
Cardiovascular risk
Weight change
Mortality
