秘宝软胶囊改善便秘作用研究

Study on Improving Constipation Function of Mibao Soft Capsule

研究秘宝软胶囊对便秘小鼠肠胃功能的调节作用。连续经口给予小鼠高剂量、中剂量、低剂量的秘宝软胶囊7d,观察秘宝软胶囊对小鼠体重的影响,然后各组灌胃复方地芬诺酯造成小鼠便秘模型,再次给予高剂量、中剂量、低剂量秘宝软胶囊,记录与模型对照组相比各剂量组小鼠小肠墨汁推进距离、小肠墨汁推进率、首次排黑便时间、6h排黑便粒数及重量情况。结果表明,低剂量组各方面均无显著性差异;中剂量组小肠墨汁推进距离、墨汁推进率增加(P<0.05),首次排黑便时间缩短(P<0.05),6h排黑便粒数、重量无显著性差异(P>0.05);高剂量组小鼠小肠墨汁推进距离、墨汁推进率明显增加(P<0.01),首次排黑便时间明显缩短(P<0.01),6h排黑便重量明显增加(P<0.01),6h排黑便粒数增加(P<0.05)。秘宝软胶囊具有明显的通便功能。

To study the regulation function of Mibao soft capsule on constipated mice.Continuous oral administration for 7 days in high,middle and low dose of Mibao soft capsule to observe the influence on mice body weight,then each group was given compound diphenoxylate by intragastric administration to develop constipation mice model.High,middle and low dose groups were given Mibao soft capsule again,compared the mice intestine ink advance distance,ink progradation rate in intestine,The time of first defecating dark stool,the number and weight of dark stool for 6 hours with model control.Results There are no significant differences between all aspects of low dose group and model control,intestine ink advance distance,ink progradation rate in intestine of middle dose group was increased（P〈0.05）,The time of first defecating dark stool was shorten（P〈0.05）,There are no significant difference of the number and weight of dark stool for 6 hours between middle dose group and model control（P：〉0.05）. The mice intestine ink advance distance,ink progradation rate in intestine（P〈0.01）,the number（P〈0.05）and weight（P〈0.01）of dark stool for 6 hours were increased,the time of first defecating dark stool was shorten（P〈0.01）of high-dose group.Mibao soft capsule has obvious purge function.