血糖波动对早期糖尿病肾病患者尿微量白蛋白及炎症因子水平的影响

Effect of blood glucose fluctuation on urinary microalbumin and inflammatory factors in patients with early diabetic nephropathy

目的研究血糖波动对早期糖尿病肾病患者尿微量白蛋白及炎症因子水平的影响。方法将2015年7月至2016年7月本院收治的88例早期糖尿病肾病患者，对患者的血糖采用动态血糖检测仪检测，分为血糖平稳者fMAGE〈5．0mmol/L）45例、血糖波动者（MAGE≥5．0mmol／L）43例，分析血糖波动对患者尿微白蛋白和炎症因子水平的影响。结果血糖平稳者与血糖波动者的HbA1c、FA比较差异无统计学意义（P〉0．05）；1,5-AG、UAE比较差异有统计学意义（P〈0．05）。血糖平稳者与血糖波动者的炎症因子IGF-1、I-6、TNF—α、hs—CRP比较差异有统计学意义（P〈0．05）。结论血糖波动的加剧可以加重机体的炎症，影响糖尿病肾病患者的病情。

Objective To study the effect of blood glucose fluctuation on urinary microalbumin and inflammatory factors in patients with early diabetic nephropathy. Methods From Jul. 2015 to Jul. 2016, a total of 88 patients with early diabetic nephropathy in our hospital were taken as the clinical research objects. All patients, whose blood glucose was detected by dynamic blood glucose detector, were divided into stable blood glucose group （MAGE〈5.0 mmol/L, 45 cases） and blood glucose fluctuation group （MAGE〉5.0 mmol/L, 43 cases）. The effect of blood glucose fluctuation on urinary microalbumin and inflammatory factors was analyzed. Results There were no statistically significant differences in HbAlc and FA between these two groups （P〉0.05）; there were statistically significant differences in 1,5-AG and UAE between these two groups （P〈0.05）. There were statistically significant differences in IGF-1, IL-6, TNF-α, and hs-CRP between these two groups （P〈0.05）. Conclusion The greater fluctuation of blood glucose can aggravate inflammation of the body and affect the condition of patients with diabetic nephropathy.