胃内灌注和导泻交替进行救治有机磷中毒患者的效果观察

Effect of alternate gastric perfusion and catharsis in the treatment of patients with organophosphorus poisoning

目的探究胃内灌注和导泻交替进行及其护理在有机磷中毒救治中的应用效果。方法选取本院急诊科2013年6月至2015年6月收治的60例有机磷中毒患者，随机分为研究组和对照组，每组30例。其中对照组患者给予常规护理，研究组患者给予胃内灌注和导泻交替进行及其护理模式。对比两组患者肠道清洁时间、CHE（胆碱酯酶）恢复时间、阿托品化时间、首次排便时间、住院时间及治疗护理过程中发生中间综合征的例数。结果研究组患者肠道清洁时间为（11．7±3．2）h，CHE恢复时间为（4．1±1．5）d，阿托品化时间（48．7±12．7）min，首次排便时间（17．4±3．5）h，住院时间为（6．3±3．2）d；对照组患者肠道清洁时间为（16．8±4．1）h，CHE恢复时间为（5．3±2．4）d，阿托品化时间（65．6±14．5）min，首次排便时间（39．9±5．7）h，住院时间为（9．5±4．4）d；研究组患者肠道清洁时间、CHE恢复时间、阿托品化时间、首次排便时间、住院时间均显著少于对照组（P〈0．05）。研究组患者发生中间综合征的比例显著少于对照组（χ^2=4．043，P〈0．05）。结论胃内灌注和导泻交替进行及其护理在有机磷中毒救治中的临床效果显著，是一种安全有效的抢救措施，值得推广应用。

Objective To study the effect of alternate gastric perfusion and catharsis, and corresponding nursing in the treatment of patients with organophosphorus poisoning. Methods 60 cases of organophosphorus poisoning treated in our hospital from June 2013 to June 2015 were randomly divided into study group and control group with 30 cases in each group. The patients in control group were given routine nursing care, while the patients in study group were given alternate gastric perfusion and catharsis, and corresponding nursing. The intestinal cleaning time, CHE recovery time, atropine time, first defecation time, length of hospital stay, and the cases of intermediate syndrome were compared between two groups. Results In study group, the intestinal cleaning time was （11.7±3.2） h, CHE recovery time was （4.1±1.5）d, atropine time was （48.7±12.7）min, first defecation time was （17.4±3.5）h, hospitalization time was （6.3±3.2）d, which were all significantly less than （16.8±4.1）h, （5.3±2.4）d, （65.6±14.5）min, （39.9±5.7）h, （9.5±4.4）d in control group （P〈0.05）. The rate of intermediate syndrome in study group was significantly less than that in control group （χ^2=4.043, P〈0.05）. Conclusion Alternate gastric perfusion and catharsis, and corresponding nursing has remarkable clinical effect, in the treatment of patients with organophosphorus poisoning, which is a kind of safe and effective rescue measure, worthy of popularization and application.