高渗盐水雾化吸入治疗毛细支气管炎的疗效观察

Observation on the efficacy of aerosol inhaled hypertonic saline in treatment of capillary bronchitis

目的观察高渗盐水雾化吸入对毛细支气管炎患儿的临床疗效。方法选取我院住院治疗的毛细支气管炎患儿116例,随机分成治疗组(62例)和对照组(54例),治疗组在常规治疗基础上加用3%高渗盐水4 m L q8h雾化吸入治疗,对照组给予生理盐水4 m L q8h雾化吸入。记录并比较两组患儿治疗后的临床严重程度(CS)评分、喘息消失时间、咳嗽消失时间、肺部啰音吸收时间以及住院天数,评估临床疗效。结果与对照组相比,治疗组治疗24h、48h、72h后CS评分下降更明显(P<0.05),治疗组患儿喘息消失时间、咳嗽消失时间、肺部啰音吸收时间,均较对照组短(P<0.05),两组住院天数和有效率比较,差异无统计学意义(P>0.05)。结论高渗盐水雾化吸入能更快降低临床CS评分,改善症状体征,但不能明显缩短病程。

Objective To observe the clinical efficacy of aerosol inhaled hypertonic saline for children with capillary bronchitis. Methods 116 children with capillary bronchitis, who were hospitalized for treatment of capil- lary bronchitis, were randomly divided into the treatment group （62 cases） and the control group （54 cases）. The treatment group was treated with aerosol inhaling 4mL 3% hypertonic saline q8h in addition to conventional therapy, and the control group was provided with aerosol inhaling 4mL saline qSh. Their clinical severity score, disappear time of wheezing, coughing, pulmonary rale and duration of hospital stay were recorded. The clinical efficacy was evalua- ted and the data were statistically analyzed. Results Compared with the control group, the clinical efficacy score of the treatment group at 24 hours, 48 hours and 72 hours after treatment decreased more obviously （ P 〈 0. 05 ）. The disappear time of wheezing, coughing and pulmonary rale of the treatment group were more shortened than those of the control group （ P 〈 0. 05 ）. There was no significant difference in duration of hospital stay between the treatment group and the control group （ P 〉 0. 05 ）. Conclusion Aerosol inhaled hypertonic saline could decrease clinical severity score and improve the clinical efficacy more effectively, but it could not shorten the course of disease.