消化腺神经内分泌肿瘤性疾病预后影响因素分析

Study on prognostic factors of neuroendocrine neoplasms in digestive gland

目的:探讨消化腺神经内分泌肿瘤性疾病病理特征、护理对策及临床预后。方法:选取2011年4月至2015年6月在我院诊断并治疗的51例患者为研究对象,采用回顾性分析方法,通过病例资料分析其临床病理特征及护理方案;随访5年后,分析其预后影响因素及护理对策。结果:消化腺神经内分泌肿瘤临床分期以Ⅲ~Ⅳ期(71.1%)占比最高;肿瘤分级以G1(53.3%)占比最高;无淋巴结转移占84.4%;无组织浸润占68.9%;分化程度以中分化(53.3%)占比最高。而临床分期、肿瘤分级、肿瘤大小、淋巴结是否转移、组织是否有浸润、分化程度、手术切缘是否阳性是5年生存率的影响因素。结论:消化腺神经内分泌肿瘤临床病理以临床Ⅲ~Ⅳ期、G1、无淋巴结转移、无组织浸润、中分化为主;5年生存率与临床分期、肿瘤分级、肿瘤大小、淋巴结转移、组织浸润、分化程度、手术切缘阳性相关。护理干预能改善患者预后。

Objective：To investigate pathological features,nursing methods and clinical prognosis of the digestive gland neuroendocrine tumor. Methods：51 patients were selected in our hospital from april 2011 to June 2015. Retrospective study were used to analyzed clinical pathological features and nursing plan by data analysis. After 5 years of follow-up,the prognostic factors and nursing strategies were analyzed. Results：The clinical stage of neuroendocrine tumors of the digestive gland was highest（71.1%）. Tumor grade was G1（53.3%）accounted for the highest;no lymph metastasis stammer accounted for 84.4%;no tissue infiltration accounted for 68.9%;the degree of differentiation in differentiation（53.3%）accounted for the highest. Clinical stage,tumor grade,tumor size,lymph node metastasis,whether there is invasion,differentiation degree,surgical resection margin was impact factors of the 5 year survival rate. Conclusion：The clinicopathological features of the neuroendocrine tumors in the digestive gland were clinical stage Ⅲ to Ⅳ,G1,no lymph node metastasis,no infiltration and moderately differentiated.The 5-year survival rate was correlated with the clinical stage,tumor grade,tumor size,lymph node metastasis,histological infiltration and differentiation. Nursing intervention could improve the prognosis of patients.