曲美他嗪联合参麦注射液对充血性心衰患者的疗效观察

Efficacy of trimetazitine combining with Shen Mai injection in patients with congestive heart failure

目的探讨曲美他嗪联合参麦注射液治疗充血性心衰的临床疗效及对患者血浆NT-pro BNP的影响。方法选取2014年1月~2016年2月本科收治的心衰患者66例,随机分为治疗组和对照组。对照组28例患者给予常规抗心衰药物治疗,治疗组38例患者在此基础上加用曲美他嗪联合参麦注射液治疗,进而对疗效进行测评。结果治疗组有效率为94.74%,高于对照组的71.43%(P<0.01);治疗后两组患者血浆NT-pro BNP水平、LVSD、LVDD明显降低,LVEF显著升高,但治疗组NT-pro BNP、LVSD、LVEF改善更为明显,差异有统计学意义(P<0.05)。结论曲美他嗪联合参麦注射液治疗充血性心力衰竭,可改善患者心功能状况,降低患者血浆NT-pro BNP水平。

Objective To investigate the clinical efficacy of trimetazidine combined with ShenMai injection in the treat- ment of patients with congestive heart failre and the effect on plasma NT-proBNP of patients. Methods A total of 66 heart failure patients who were treated in our department from January 2014 to February 2016 were-selected, randomly divided into treatment group and control group. 28 patients in the control group were given routine anti heart failure drug treatment, while 38 patients in the treatment group were given the additional therapy of trimetazidine combined with ShenMai injection. Then the curative effect can be evaluated. Results The treatment effective rate was 94.74% in the treatment group, higher than that in the control group（71.43%）. After the treatment,plasma NT-proBNP,LVSD, LVDD were reduced, and LVEF was increased in both of the groups, But the improvement of NT-proBNP, LVSD, LVEF were more significant in the treatment group, and the differences were statistically significant （P〈0.05）. Con- clusion The combined application of trimetazitine combining with ShenMai injection is able to significantlY reduce the plasma NT-proBNP in patients with congestive heart failure, and is able to significantly improve the cardiac function.