碘海醇与碘克沙醇对增强CT检查患者肾功能影响的对比研究

Effects of iohexol and iodixanol on renal function in patients with enhanced CT

目的比较增强CT检查中低渗造影剂碘海醇和等渗造影剂碘克沙醇对患者肾功能的影响。方法收集2016年5—6月在山西医科大学第二医院行增强CT检查的81例住院患者的病历资料，根据使用造影剂的不同分为碘海醇组（43例）和碘克沙醇组（38例）。检测并比较2组患者造影前及造影后第1、3、7天的血肌酐水平；记录2组患者造影剂肾病（CIN）发生情况。结果碘海醇组和碘克沙醇组患者造影后第1、3、7天血肌酐水平与造影前比较[（71±15）、（70±14）、（67±17）μmoL／L比（68±15）μmoVL，（71±11）、（70±10）、（69±11）μmol／L比（69±11）μmol]，差异均无统计学意义（均P〉0．05）；造影前及造影后第1、3、7天2组患者血肌酐水平组间比较，差异均无统计学意义（均P〉0．05）。碘海醇组CIN发生率为9．3％（4／43），碘克沙醇组CIN发生率为2．6％（1／38），2组间比较差异无统计学意义（P=0．364）。结论碘海醇与碘克沙醇对肾功能的影响均较小，在危险因素较低的人群中使用较安全。

Objective To analyze effects of low-osmolar contrast media iohexol and isotonic contrast media iodixanol on renal function in patients with enhanced CT. Methods A total of 81 patients who had enhanced CT from May to June 2016 in the Second Hospital of Shanxi Medical University were enrolled. The patients were divided into iohexol group（43 cases） and iodixanol group（38 cases）. Serum creatinine levels before angiography and at the 1st, 3rd, 7th day after angiography were analyzed. The occurrence of contrast induced nephropathy （CIN） was recorded. Results Serum creatinine levels at the 1st, 3rd, 7th day after angiography had no significant differences compared to those before angiography in both groups[ iohexol group： （71 ± 15 ）, （70 ± 14）, （67 ± 17 ） μ mol/L vs （ 68 ± 15 ） μmol/L ; iodixanol group ： （ 71 ± 11 ）, （ 70 ± 10 ）, （ 69 ± 11 ） μmoL/L vs （69 ± 11 ） μmol/L ] （ P 〉 0. 05 ） ; the differences between groups were not significant （ P 〉 0. 05 ）. The incidence of CIN in iohexol group was 9.3% （4/43） and the incidence of CIN in iodixanol group was 2. 6% （ 1/38）, there was no significant difference between groups（P = 0. 364）. Conclusion Both Iohexol and iodixanol have little effect on renal function.