银屑病患者非酒精性脂肪肝发生率和相关临床指标分析

Prevalence of Non-alcoholic Fatty Liver Disease in Patients with Psoriasis and Analyze the Associated Clinical Characteristics

目的调查我院银屑病患者中非酒精性脂肪肝(NAFLD)的发生率。方法纳入120例银屑病患者和年龄及性别相匹配的98例对照病例,应用腹部超声检测2组中NAFLD的发生率。同时,测定血清谷丙转氨酶(ALT)、天冬氨酸转氨酶(AST)、γ-谷氨酰转移酶(GGT)、总胆固醇(TC)、高密度脂蛋白(HDL-L)、低密度脂蛋白(LDL-L)、甘油三酯(TG)及空腹血糖(FBS)水平。结果银屑病组中NAFLD发病率升高(46.7%vs.30.6%,P=0.016)。银屑病并发与无并发NAFLD者比较,2组血清AST、TC、HDL-L及LDL-L相比差异无统计学意义。银屑病并发NAFLD者血清ALT、GGT、TG和FBS明显高于无并发者(均P<0.01)。结论银屑病易并发NAFLD,合并NAFLD银屑病患者常伴随肝酶、血脂及血糖代谢异常。

Objective In order to investigate the prevalence of non-alcoholic fatty liver disease （NAFLD） in patients with psoriasis. Methods A total of 120 patients with chronic plaque psoriasis and 98 healthy controls matched for age and sex were enrolled. NAFLD was diagnosed by abdominal ultrasound after excluding other secondary causes of chronic liver disease. Results The prevalence of NAFLD was higher in the psoriatic group compared with the control group （46.7% vs. 30.6%,P= 0.016）. Patients with psoriasis and NAFLD tended to have higher levels of serum ALT, GGT, triglyceride and fasting blood sugar （FBS） than psoriasis without NAFLD. Conclusion NAFLD is frequent in patients with chronic plaque psoriasis. Psoriasis with NAFLD is accompanied by abnormal of serum liver enzymes, blood lipid and sugar.