摘要
目的探讨精神分裂症和强迫症记忆监测的特点。方法对符合DSM.5相应诊断标准的44例精神分裂症患者和42例强迫症患者以及51例正常健康对照进行情景记忆知晓感(FOK)的测验。结果精神分裂症患者线索回忆和再认正确率[0.30(0.15,0.50),0.75(0.56,0.90)]均低于正常对照[0.70(0.50,0.85),0.95(0.85,1.00)]和强迫症患者[0.65(0.39,0.76),0.95(0.84,1.00)],差异具有统计学意义(均P〈0.01)。强迫症患者线索回忆的正确率低于正常对照,差异有统计学意义(P〈0.05)。在高估方面,三组[0.2l(0.00,0.32),0.15(0.00,0.33),0.09(0.00,0.25)]均差异无统计学意义(P〉0.05)。在低估上,精神分裂症患者[0.12(0.00,0.36)]高于强迫症患者[0.00(0.00,0.20)]和正常对照[0.00(0.00,0.22)],差异有统计学意义(分别为P〈0.05,P〈0.01),强迫症患者和正常对照差异无统计学意义(P〉0.05)。精神分裂症患者的Hamann系数[0.19(-0.11,0.43)]低于强迫症患者[0.41(0.13,0.78)]和正常对照[0,56(0.14,1.00)],差异有统计学意义(P〈0.01),强迫症患者和正常对照差异无统计学意义(P〉0.05)。精神分裂症患者(r:0.39,P〈0.01)和正常对照(r=0.52,P〈0.001)的回忆正确率和Hamann系数成正相关。结论精神分裂症患者和强迫症患者的情景记忆均受损,但精神分裂症患者的记忆监测能力受损,强迫症患者完整。
Objective To compare the features of memory monitoring between schizophrenia and obsessive-compulsive disorder in patients. Methods 44 schizophrenia patients and 42 obsessive-compulsive disorder patients who met the DSM-V diagnosis and 51 healthy controls were assessed with feeling-of-knowing (FOK) for episode memory test. Results Schizophrenia patients had significantly poorer cued recall and recognition performance ( 0.30(0.15,0.50) , 0.75 (0.56,0.90) ) compared with healthy controls ( 0.70 ( 0.50, 0.85 ) , 0.95 ( 0.85,1.00) ) and obsessive-compulsive disorder patients ( 0.65 (0.39,0.76) , 0.95 ( 0.84,1.00) ) (all P〈0.001 ).There was significant difference between obsessive-compulsive disorder patients and healthy controls in cued recall performance(P〈0.05).There was no difference among the three groups in overestimate index ( 0.21 (0.00,0.32) , 0. 15 ( 0.00,0.33 ) , 0.09 ( 0. 00,0.25 ) , all P〉 0.05 ). In underestimate index, schizophrenia patients' values ( 0.12 ( 0.00,0.36 ) ) were significantly higher than that of healthy controls ( 0.00 (0.00,0.22)) and obsessive-compulsive disorder patients(0.00(0.00,0.20) ) ( P〈0.05, P〈0.01 ) ,but there was no difference between obsessive-compulsive disorder patients and healthy controls(P〉0.05 ).Schizophre- nia patients' Hamann index ( 0.19 ( -0.11,0.43 ) ) was significantly lower than that of healthy controls ( 0.56 ( 0.14,1.00) ) and obsessive-compulsive disorder patients( 0.41 ( 0.13,0.78 ) ) (P〈0.01) , but there was no difference between obsessive-compulsive disorder patients and healthy controls(P〉0.05).Cued recall performance was positively correlated with Hamann index in patients with schizophrenia ( r= 0.39, P〈 0.01 )and healthy controls( r= 0.52, P〈 0.001 ). Conclusion Patients with schizophrenia and obsessive-compulsive disorder both have episode memory impairments, memory monitoring impairment is observed in schizophrenia patients, but not in obsessive-compulsive disorder patients.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2017年第2期118-122,共5页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金项目(31571149)
安徽医科大学博士科研资助项目(XJ201533)
关键词
精神分裂症
强迫症
情景记忆
记忆监测
知晓感
Schizophrenia
Obsessive-compulsive disorder
Episodic memory
Memory monitoring
Feeling of knowing