酒精依赖患者内隐认知偏倚的事件相关电位研究

Study of event-related potentials on implicit cognitive basis in patients with alcohol dependence

目的探讨酒精依赖患者内隐认知偏倚的事件相关电位特征。方法对酒精依赖患者（30例）和健康者（30例）进行内隐认知任务（IAT）的事件相关电位（ERPs）检测，分析二组的IAT与ERPs数据结果。结果研究组图片类型与态度词交互作用显著[F（1,29）=32．08，P=0．003]，对与酒精有关图片一正性态度词以及与酒精无关图片一负性态度词的反应时[（653．2±42．3）ms，（698．5±38．1）ms]短于对与酒精无关图片．正性态度词[（680．2±40．1）ms]以及与酒精有关图片-负性态度词的反应时[（713．3±43．3）ms][F（1,29）=28．08、37．06，P=0．002、0．000]。研究组图片类型与态度词主效应显著[F（1,29）=37．88、43．08，[P=0．004、0．002]，对酒精相关图片反应时短于对酒精无关图片反应时。研究组对与酒精有关图片．正性态度词反应时明显快于对照组[（710．0±32．3）ms]（P=0．009）。研究组图片类型与态度词的P3波幅交互作用显著[F（1,29）=24．34，P=0．003]，对与酒精有关图片-正性态度词的P3波幅明显高于与酒精有关图片-负性态度词的P3波幅[F（1,29）=8．87，P=0．030]。对与酒精无关图片-负性态度词的P3波幅明显高于与酒精无关图片-正性态度词的P3波幅[F（1,29）=7．63，P=0．028]。图片类型、态度词以及电极位点之间存在交互作用[F（4,116）=11．20，P=0．001]，图片类型与态度词在额部、额部．中线以及中线电极位点交互作用显著[F（1,29）=17．20、21．78、19．67，P=0．008、0．001、0．021]。结论酒精依赖患者存在对酒精有关图片信息的注意偏倚，前额部以及中线部位大脑皮质是这种偏倚的神经生理基础。

Objective To investigate the event-related potentials （ERPs） characters of implicit cognitive basis in patients with alcohol dependence （AD）. Methods Implicit association task and ERPs were detected in 30 individuals with alcohol dependence and 30 controls. Results In patients group, it revealed interaction between picture type and attitude words （ F（1,29）= 32.08, P = 0.003 ） , and RTs to alcohol-related picture-positive words（（653.2±42.3） ms and RTs to non-alcohol-related picture-negative words（ （698.5±38. 1 ）ms ） were faster than those of non-alcohol-related picture-positive words（（680.2±40.1） ms） and alcohol- related picture-negative words（（713.3±43.3） ms）.Additionally, the main effects of picture type and attitude words was significant.RTs to alcohol-related picture were faster than those to non-alcohol-related picture. RTs to alcohol-related picture-positive words in patient group were faster than those of controls （ （710.0±32.3 ） ms, P= 0.009）.In patients group,it revealed interaction between P3 amplitudes for picture type and attitude words.P3 amplitudes to alcohol-related picture-positive words were higher than those of P3 amplitudes to al- cohol-related picture-negative words. Interaction among picture type, attitude words and electrode sites was significant in patient group. Conclusions Patients with alcohol dependence present implicit cognitive basis to alcohol related information ,and fi：ont ,front-central and central are neurophysiological architecture.