近红外光成像技术辅助诊断抑郁症的灵敏度和特异度研究

Study of the sensitivity and specificity on near-infrared spectroscopy in diagnosis of depression

目的探讨近红外光成像技术（near—infrared spectroscopy，NIRS）的波形特点及检测抑郁症的灵敏度和特异度。方法对2013年3～8月在北京大学第六医院就诊的62例抑郁症患者和70例正常对照组进行NIRS数据采集。采用脑功能定量成像装置仪（52通道），在被试完成言语流畅性任务（verbal fluency test，VFT）的同时采集NIRS数据，并记录组词个数。由一名经过专业培训过的精神科技师分析波谱变化特点。结果抑郁症组[（8．65±0．49）个]与正常对照组[（10．19±0．43）个]在VFT平均组词个数上差异有统计学意义（t=2．385，P〈0．05）。通过波谱判断NIRS检测抑郁症患者，灵敏度为66．1％，特异度91．4％。结论NIRS检测对抑郁症患者特异度较高，可作为临床上辅助诊断抑郁症的客观指标之一。

Objective To explore the sensitivity and specificity of near-infrared spectroscopy （NIRS） in the diagnosis of depression. Methods From March 2013 to August 2013,62 patients with depression and 70 normal controls were collected from Peking University Sixth Hospital. Optical Tomography System （52 channels） was used to collect the NIRS data during the Verbal Fluency Test （VFT）, and the number of words produced during VFT task was recorded. The wave analysis was performed by a professional psychiatrist. Results There was statistical difference in the number of words produced during VFT task between the patients with depression （ 8.65± 0.49 ） and control group （ 10.19±0.43 ） （ t = 2.385, P〈 0.05 ）. Through the wave analysis of NIRS to test patients with depression, the results demonstrated that the sensitivity was 66.1% and the specificity was 91.4%. Conclusion The results of NIRS test display high specificity in the diagnosis of depression, which can be used as an objective index for clinical auxiliary diagnosis.