胰腺癌中PcG相关蛋白RYBP的表达及临床意义

Expression of Pc G related protein RYBP in pancreatic carcinoma and its clinical significance

目的探讨Pc G相关蛋白RYBP在胰腺癌中的表达及其临床意义。方法采用免疫组化法检测51例胰腺癌及对应癌旁组织中RYBP的表达,分析其表达与胰腺癌临床病理特征的关系。Kaplan-Meier法分析RYBP表达与胰腺癌患者术后生存时间的关系。结果 RYBP在胰腺癌中的阳性率(31.4%,16/51)明显低于癌旁组织(66.7%,34/51),两者差异有统计学意义(P<0.05)。RYBP表达与患者性别、年龄、吸烟、饮酒、肿瘤数目、有无淋巴结转移和血清CA199水平无明显相关性(P>0.05),与肿瘤直径及肿瘤病理分级有相关性(P<0.05)。Kaplan-Meier法分析显示RYBP阳性组患者的总生存率明显高于阴性组(P<0.05)。结论 Pc G相关蛋白RYBP在胰腺癌中低表达,RYBP表达降低可能与胰腺癌发生、发展密切相关。

Purpose To investigate the expression and clinical significance of RINGI and YYI binding protein （RYBP） in pancreatic carcinoma （PC）. Methods RYBP expression was detected in 51 cases of PC tissues and paired adjacent nontumor tissues by immunohistochemistry. The correlation between RYBP expression and the survival time of PC patients after surgery was analyzed by Kaplan-Meier method. Results Compared to the expression in adjacent non-tumor tissues, RYBP was significantly lower expressed in PC tissues （P 〈 0. 05）. In addition, RYBP expression had a significant correlation with tumor diameter and tumor staging of patients （ P 〈 0. 05 ）, but no significant correlation with other characteristics of patients, such as gender, age, smoking, alcohol intake, tumor number, metastasis or CA199 level （ P 〉 0. 05 ）. The survival analysis showed that the survival time of PC patients with positive expression of RYBP was significantly longer than patients with negative expression of RYBP （P 〈 0. 05）. Conclusion RYBP is significantly lower expressed in PC tissues, which might be involved in the pathogenesis of PC.