摘要
背景子宫内膜异位症（endometriosis，EMT）是育龄期妇女最常见的疾病之一，慢性顽固性疼痛是其最主要的临床症状，近年来研究发现EMT疼痛合并有明显的神经系统变化。目的综述EMT疼痛的神经机制。内容综述EMT疼痛的动物模型及特点、外周及中枢敏化机制以及脊髓电刺激（spinal cord stimulation, SCS）对EMT疼痛的治疗效应。趋向阐明EMT痛敏机制，可望为该病的疼痛管理提供新方法。
Background Endometriosis （EMT） is one of the most common diseases in women of reproductive age, whose predominant clinical symptom is intractable chronic pain. Recent studies indicate that EMT-associated pain is related to significant changes in the nervous system. Objective To review the neural mechanisms underlying EMT-associated pain. Content To review the animal models and characteristics of EMT-associated pain, mechanisms of peripheral and central sensitization, and the effect of spinal cord stimulation （SCS） on the treatment of EMT-associated pain. Trend To illuminate the mechanisms underlying EMT-associated hyperalgesia may provide a new viable method for the management of EMT-associated pain.
出处
《国际麻醉学与复苏杂志》
CAS
2017年第2期171-174,共4页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金（30801073）
北京市卫生系统高层次卫生人才（学科骨干）培养计划
关键词
子宫内膜异位症
外周敏化
中枢敏化
Endometriosis
Peripheral sensitization
Central sensitization
